用于治疗抑郁症或焦虑症的氘代1,3-二氢-2-吲哚-2-酮衍生物
Deuterated 1,3 Dihydro‑2‑indole-2-one Derivatives for Treatment of Depression or Anxiety.
作者信息
Hu Qi-Long, Liang Steven H
机构信息
Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, Georgia 30322, United States.
出版信息
ACS Med Chem Lett. 2025 May 28;16(6):965-966. doi: 10.1021/acsmedchemlett.5c00284. eCollection 2025 Jun 12.
Abstract
This patent application discloses a series of l,3-dihydro-2-indol-2-one derivatives targeting the vasopressin 1b receptor (V) or both the V and V receptors, as represented by Formula I. These vasopressin receptor antagonists exhibit significant therapeutic potential, particularly for the treatment of depression or anxiety, and hold promises for benefiting patients with reduced dosing frequency.
摘要
本专利申请公开了一系列靶向血管加压素1b受体（V）或V和V受体的1,3 - 二氢 - 2 - 吲哚 - 2 - 酮衍生物，如式I所示。这些血管加压素受体拮抗剂具有显著的治疗潜力，特别是用于治疗抑郁症或焦虑症，并且有望通过降低给药频率使患者受益。
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本文引用的文献
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