新型精氨酸加压素受体1A（AVPR1A）拮抗剂的合成与应用
Synthesis and Application of Novel Arginine Vasopressin Receptor 1A (AVPR1A) Antagonists.
作者信息
Zhou Xin, Liang Steven H
机构信息
Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, Georgia 30322, United States.
出版信息
ACS Med Chem Lett. 2025 May 29;16(6):963-964. doi: 10.1021/acsmedchemlett.5c00285. eCollection 2025 Jun 12.
Abstract
Arginine Vasopressin Receptor 1A (AVPR1A) is a member of G-protein-coupled receptors (GPCRs) that binds arginine vasopressin (AVP) and is primarily related to cardiovascular function, glycogenolysis, and social behaviors. This patent describes the synthesis of a series of AVPR1A antagonists and their applications in related disease treatment.
摘要
精氨酸加压素受体1A（AVPR1A）是G蛋白偶联受体（GPCRs）家族的成员，它与精氨酸加压素（AVP）结合，主要涉及心血管功能、糖原分解和社会行为。本专利描述了一系列AVPR1A拮抗剂的合成及其在相关疾病治疗中的应用。
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