新型精氨酸加压素受体1A（AVPR1A）拮抗剂的合成与应用
Synthesis and Application of Novel Arginine Vasopressin Receptor 1A (AVPR1A) Antagonists.
作者信息
Zhou Xin, Liang Steven H
机构信息
Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, Georgia 30322, United States.
出版信息
ACS Med Chem Lett. 2025 May 29;16(6):963-964. doi: 10.1021/acsmedchemlett.5c00285. eCollection 2025 Jun 12.
Abstract
Arginine Vasopressin Receptor 1A (AVPR1A) is a member of G-protein-coupled receptors (GPCRs) that binds arginine vasopressin (AVP) and is primarily related to cardiovascular function, glycogenolysis, and social behaviors. This patent describes the synthesis of a series of AVPR1A antagonists and their applications in related disease treatment.
摘要
精氨酸加压素受体1A（AVPR1A）是G蛋白偶联受体（GPCRs）家族的成员，它与精氨酸加压素（AVP）结合，主要涉及心血管功能、糖原分解和社会行为。本专利描述了一系列AVPR1A拮抗剂的合成及其在相关疾病治疗中的应用。
相似文献
1
Synthesis and Application of Novel Arginine Vasopressin Receptor 1A (AVPR1A) Antagonists.
ACS Med Chem Lett. 2025 May 29;16(6):963-964. doi: 10.1021/acsmedchemlett.5c00285. eCollection 2025 Jun 12.
2
Involvement of the AVP/OT System and Lateral Septum in the Modulation of Anxiety/Depression Caused by 14-Week and 20-Week Social Isolation.
Neuroendocrinology. 2025;115(6-7):493-519. doi: 10.1159/000544839. Epub 2025 Feb 25.
3
Effects on gene expression and behavior of untagged short tandem repeats: the case of arginine vasopressin receptor 1a (AVPR1a) and externalizing behaviors.
Transl Psychiatry. 2018 Mar 27;8(1):72. doi: 10.1038/s41398-018-0120-z.
4
Sex differences in the structure and function of the vasopressin system in the ventral pallidum are associated with the sex-specific regulation of social play behavior in juvenile rats.
Horm Behav. 2024 Jul;163:105563. doi: 10.1016/j.yhbeh.2024.105563. Epub 2024 May 20.
5
Linked Variants Are Associated with Social Behavior Differences in Bonobos ().
bioRxiv. 2023 Dec 23:2023.12.22.573122. doi: 10.1101/2023.12.22.573122.
6
Effects of environmental toxicant exposures on oxytocin and vasopressin systems in the developing brain: factors imparting risk and resilience.
Behav Brain Res. 2025 Oct 2;494:115723. doi: 10.1016/j.bbr.2025.115723. Epub 2025 Jul 3.
7
Effects of peritoneal dialysis fluids on arginine vasopressin dynamics in humans and transgenic rats.
Perit Dial Int. 2025 Jun 23:8968608251347093. doi: 10.1177/08968608251347093.
8
Disrupted ACTH and cortisol response to osmotic and non-osmotic stress in patients with arginine vasopressin deficiency.
Eur J Endocrinol. 2025 Jun 30;193(1):1-9. doi: 10.1093/ejendo/lvaf119.
9
Interventions for chronic non-hypovolaemic hypotonic hyponatraemia.
Cochrane Database Syst Rev. 2018 Jun 28;6(6):CD010965. doi: 10.1002/14651858.CD010965.pub2.
10
Management of Arginine Vasopressin Deficiency (Central Diabetes Insipidus) in Neonates and Infants.
Horm Res Paediatr. 2025 Jul 2:1-11. doi: 10.1159/000547155.
本文引用的文献
1
Discovery and evaluation of a novel F-labeled vasopressin 1a receptor PET ligand with peripheral binding specificity.
Acta Pharm Sin B. 2024 Sep;14(9):4014-4027. doi: 10.1016/j.apsb.2024.05.033. Epub 2024 Jun 3.
2
Arginine vasopressin receptor signaling and functional outcomes in heart failure.
Cell Signal. 2016 Mar;28(3):224-233. doi: 10.1016/j.cellsig.2015.07.021. Epub 2015 Jul 30.
3
Vasopressin V1a and V1b receptors: from molecules to physiological systems.
Physiol Rev. 2012 Oct;92(4):1813-64. doi: 10.1152/physrev.00035.2011.
4
Evolution of the arginine vasopressin 1a receptor and implications for mammalian social behaviour.
Prog Brain Res. 2008;170:321-30. doi: 10.1016/S0079-6123(08)00426-3.
5
Molecular cloning and expression of rat V1a and V2 arginine vasopressin receptors.
Regul Pept. 1993 Apr 29;45(1-2):53-9. doi: 10.1016/0167-0115(93)90182-8.
Zotero 插件