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2
The evolution of N, N-Dimethyltryptamine: from metabolic pathways to brain connectivity.N，N-二甲基色胺的演变：从代谢途径到脑连接性
Psychopharmacology (Berl). 2025 Apr 11. doi: 10.1007/s00213-025-06777-z.
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Psychedelic-Induced Neural Plasticity: A Comprehensive Review and a Discussion of Clinical Implications.致幻剂诱导的神经可塑性：全面综述及临床意义探讨
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4
Exploring DMT: Endogenous role and therapeutic potential.探索二甲基色胺：内源性作用及治疗潜力。
Neuropharmacology. 2025 May 1;268:110314. doi: 10.1016/j.neuropharm.2025.110314. Epub 2025 Jan 18.
5
Novel Ergoline Compounds as 5-HT2A Agonists for Treating Mood Disorders Such as Depressive Disorders and Bipolar Disorders.新型麦角灵化合物作为5-HT2A激动剂用于治疗情绪障碍，如抑郁症和双相情感障碍。
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6
Antidepressant and anxiolytic effects of activating 5HT2A receptors in the anterior cingulate cortex and the theoretical mechanisms underlying them - A scoping review of available literature.前扣带回皮层中5HT2A受体激活的抗抑郁和抗焦虑作用及其潜在理论机制——现有文献的综述
Brain Res. 2025 Jan 1;1846:149226. doi: 10.1016/j.brainres.2024.149226. Epub 2024 Sep 7.

新型麦角灵类化合物作为5-羟色胺2A受体激动剂用于治疗情绪障碍

Novel Ergolines as 5‑HT2A Agonists for Treating Mood Disorders.

作者信息

Sabnis Ram W

机构信息

Smith, Gambrell & Russell LLP, 1105 W. Peachtree Street NE, Atlanta, Georgia 30309, United States.

出版信息

ACS Med Chem Lett. 2025 May 21;16(6):974-975. doi: 10.1021/acsmedchemlett.5c00288. eCollection 2025 Jun 12.

DOI:10.1021/acsmedchemlett.5c00288
PMID:40529079
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12169486/
Abstract

Provided herein are novel ergolines as 5-HT2A agonists, pharmaceutical compositions, use of such compounds in treating mood disorders, and processes for preparing such compounds.

摘要

本文提供了作为5-HT2A激动剂的新型麦角灵、药物组合物、此类化合物在治疗情绪障碍中的用途以及制备此类化合物的方法。