合成致死性作为癌症新兴治疗方法：以使用沃纳综合征解旋酶（WRN）抑制剂为例
Synthetic Lethality as Emerging Treatment for Cancer: An Example by Using the Werner Syndrome Helicase (WRN) Inhibitors.
作者信息
Abdel-Magid Ahmed F
机构信息
Independent Consultant, 1383 Jasper Drive, Ambler, Pennsylvania 19002, United States.
出版信息
ACS Med Chem Lett. 2025 May 20;16(6):959-962. doi: 10.1021/acsmedchemlett.5c00272. eCollection 2025 Jun 12.
Abstract
The invention in this patent application relates to chemical compounds represented herein generally by Formula 1a. These compounds are inhibitors of the Werner Syndrome ATP-dependent helicase (WRN) enzyme activity. The compounds of the invention may particularly be useful in treating cancers characterized by microsatellite instability (MSI) and/or defective DNA mismatch repair (dMMR) system.
摘要
本专利申请中的发明涉及一般由式1a表示的化合物。这些化合物是沃纳综合征ATP依赖性解旋酶（WRN）酶活性的抑制剂。本发明的化合物可能特别适用于治疗以微卫星不稳定性（MSI）和/或缺陷性DNA错配修复（dMMR）系统为特征的癌症。
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