Nazario-Pérez M Z, Quiles-Méndez A P, Pastrana-Echevarría I, Brito-Sánchez R, Ruiz-Deyá G
St. Luke's Hospital Department of Graduated Medical Education Research Fellow, 917 Av. Tito Castro, Ponce, 00733, Puerto Rico.
University of Medicine and Health Sciences, Basseterre, Saint Kitts and Nevis.
Urol Case Rep. 2025 Jun 2;61:103091. doi: 10.1016/j.eucr.2025.103091. eCollection 2025 Jul.
Testicular cancer primarily manifests as a painless mass, yet atypical presentations can hinder effective diagnosis and management. Here we present a 34-year-old male with a large, ulcerated, fungating extra-scrotal mass invading the inguinal canal. Laboratory showed markedly elevated alpha-fetoprotein, and imaging confirmed advanced disease with bilateral pulmonary metastases. The patient underwent radical orchiectomy with partial scrotectomy. Histopathology revealed a pure post-pubertal yolk sac tumor. Despite guideline-directed systemic chemotherapy, the course was complicated by tumor-related bleeding and venous thromboembolism, resulting in death from massive pulmonary embolism. This case highlights the aggressiveness of adult yolk sac tumors and need for early intervention.
睾丸癌主要表现为无痛性肿块，但非典型表现可能会妨碍有效的诊断和治疗。在此，我们报告一名34岁男性，其阴囊外有一个巨大、溃疡、呈蕈状的肿块，侵犯腹股沟管。实验室检查显示甲胎蛋白显著升高，影像学检查证实为晚期疾病并伴有双侧肺转移。患者接受了根治性睾丸切除术及部分阴囊切除术。组织病理学检查显示为单纯的青春期后卵黄囊瘤。尽管进行了指南指导下的全身化疗，但病程因肿瘤相关出血和静脉血栓栓塞而复杂化，最终因大面积肺栓塞死亡。本病例突出了成人卵黄囊瘤的侵袭性以及早期干预的必要性。
