在N-乙基-N-丁基亚硝胺影响下，大鼠远端食管缩窄加速肿瘤诱导
Accelerated tumor induction by distal esophageal constriction in the rat under the influence of N-ethyl-N-butyl-nitrosamine.
作者信息
Sons H U, Borchard F, Müller-Jäh K, Sandmann H
出版信息
Cancer. 1985 Dec 1;56(11):2617-21. doi: 10.1002/1097-0142(19851201)56:11<2617::aid-cncr2820561114>3.0.co;2-q.
Abstract
When given N-ethyl-N-butyl-nitrosamine, which was added to the drinking water, a statistically significantly greater number of esophageal papillomas developed in rats with an operatively produced stenosis of the distal esophagus than in control rats without stenosis. The tumor induction occurred earlier in the rats that had undergone surgery, and the preferred site was in the area of the stenosis.
摘要
当给大鼠饮用添加了N-乙基-N-丁基亚硝胺的水时，与未发生狭窄的对照大鼠相比，手术造成远端食管狭窄的大鼠发生食管乳头状瘤的数量在统计学上显著更多。肿瘤诱导在接受手术的大鼠中出现得更早，且好发部位在狭窄区域。
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