Andrion A, Mazzucco G, Gugliotta P, Monga G
Cancer. 1985 Dec 1;56(11):2657-63. doi: 10.1002/1097-0142(19851201)56:11<2657::aid-cncr2820561121>3.0.co;2-u.
A case of a benign clear cell "sugar" tumor of the lung is reported. Light microscopy showed a uniform proliferation of clear cells filled with abundant glycogen. At the ultrastructural level, tumor cells were rich in free monogranular and rosette-forming glycogen, but no membrane-bound glycogen was demonstrated. Some cells showed plasma membrane interdigitations, microvilli, and macula occludens-type junctions. Many polymorphic secretory and sporadic haloed neurosecretory-like granules were observed, but argyrophil stains as well as a large set of immunohistochemical reactions specific for APUD derivation had negative results. A literature review of this puzzling entity with particular emphasis on the histogenetic hypotheses is presented, and a derivation from epithelial nonciliated bronchiolar (Clara) cells or epithelial serous cells is suggested.
报告一例肺良性透明细胞“糖”瘤。光镜下可见充满丰富糖原的透明细胞呈均匀增殖。在超微结构水平上，肿瘤细胞富含游离单颗粒和玫瑰花结样糖原，但未显示有膜结合糖原。部分细胞可见质膜指状突起、微绒毛和紧密连接型连接。观察到许多多形性分泌颗粒和散在的晕环样神经分泌样颗粒，但嗜银染色以及一系列针对APUD起源的特异性免疫组化反应均为阴性。本文对这一令人困惑的实体进行了文献综述，特别强调了组织发生假说，并提出其起源于上皮性无纤毛细支气管（克拉拉）细胞或上皮浆液细胞。
