Frydecka I
Cancer. 1985 Dec 15;56(12):2799-803. doi: 10.1002/1097-0142(19851215)56:12<2799::aid-cncr2820561215>3.0.co;2-w.
Natural killer (NK) activity was investigated in 61 patients with Stage III and IV Hodgkin's disease during the course of disease and in 30 healthy age- and sex-matched healthy volunteers. The mean NK activity was significantly lower (P less than 0.001) in untreated patients and in patients in the active phase of the disease during treatment, compared with controls. There was a similar mean value of NK activity in normal subjects, compared with patients in clinical remission. NK activity correlated with the response to therapy. In patients responding to treatment, NK activity was increasing, reaching normal range in remission. The patients not responding to therapy showed gradual decrease of NK activity during the course of disease. These results suggest that the study of NK function might offer a helpful tool in following the clinical course and the efficacy of therapy, as well as for monitoring cancer patients from an immunologic viewpoint.
对61例Ⅲ期和Ⅳ期霍奇金病患者在病程中以及30名年龄和性别匹配的健康志愿者进行了自然杀伤（NK）活性研究。与对照组相比，未经治疗的患者以及治疗期间处于疾病活动期的患者的平均NK活性显著降低（P<0.001）。与临床缓解期的患者相比，正常受试者的NK活性平均值相似。NK活性与治疗反应相关。在对治疗有反应的患者中，NK活性增加，缓解期达到正常范围。对治疗无反应的患者在病程中NK活性逐渐降低。这些结果表明，研究NK功能可能为跟踪临床病程和治疗效果提供有用的工具，以及从免疫学角度监测癌症患者。
