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黑人及西班牙裔/拉丁裔疼痛性周围神经病变患者皮质脊髓兴奋性的经颅磁刺激测量

Transcranial magnetic stimulation measures of corticospinal excitability in Black and Hispanic/Latino people with painful peripheral neuropathy.

作者信息

Wong Marlon L, McTeague Lisa M, Gonzalez Gabriel, Gonzalez Juan P, Bolanos Jessica L, Hosein Peter J, Cabral Danylo F, Fried Peter J

机构信息

Department of Physical Therapy, University of Miami, Coral Gables, FL, United States.

Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, United States.

出版信息

Front Hum Neurosci. 2025 Jun 2;19:1551931. doi: 10.3389/fnhum.2025.1551931. eCollection 2025.

DOI:10.3389/fnhum.2025.1551931
PMID:40529545
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12171121/
Abstract

INTRODUCTION

This study aims to provide preliminary descriptive data on transcranial magnetic stimulation (TMS) measures obtained in Black and Hispanic/Latino individuals with chronic painful peripheral neuropathy (PN), including those with chemotherapy-induced peripheral neuropathy (CIPN) and diabetic neuropathy (DN). Both CIPN and DN share similar neuropathic symptoms and underlying physiological mechanisms, in particular altered central nervous system processing. TMS is a non-invasive technique that can assess corticospinal excitability and the function of GABAergic and glutamatergic pathways, potentially serving as a diagnostic or prognostic tool for PN.

METHODS

This study utilized data from a pilot randomized sham-controlled trial that tested the impact of patient education videos on the effect of transcutaneous auricular vagus nerve stimulation (taVNS) in Black and Hispanic/Latino individuals living with PN. TMS measures, including resting motor threshold (RMT), MEP amplitude following unconditioned single-pulse TMS (spTMS) and paired-pulse TMS measures of short interval intracortical inhibition (SICI), and intracortical facilitation (ICF), were assessed twice on separate visits. Test-retest reliability was evaluated, and changes in TMS measures following transcutaneous auricular vagus nerve stimulation were computed.

RESULTS

Pre-intervention TMS measures showed smaller-than-medium sized differences between CIPN and DN groups. The study found good test-retest reliability for TMS measures, with ICC values between 0.69 and 0.95 for all TMS measures of interest.

DISCUSSION

Overall, TMS measures demonstrated good reliability in this sample of Black and Hispanic/Latino individuals with PN, and these findings provide valuable preliminary data for future studies aimed at establishing the psychometric properties and diagnostic utility of TMS measures in PN.

摘要

引言

本研究旨在提供关于慢性疼痛性周围神经病变（PN）的黑人及西班牙裔/拉丁裔个体经颅磁刺激（TMS）测量的初步描述性数据，包括那些患有化疗引起的周围神经病变（CIPN）和糖尿病性神经病变（DN）的个体。CIPN和DN都有相似的神经病变症状和潜在的生理机制，特别是中枢神经系统处理过程的改变。TMS是一种非侵入性技术，可以评估皮质脊髓兴奋性以及γ-氨基丁酸能和谷氨酸能通路的功能，有可能作为PN的诊断或预后工具。

方法

本研究利用了一项初步随机假对照试验的数据，该试验测试了患者教育视频对患有PN的黑人和西班牙裔/拉丁裔个体经皮耳迷走神经刺激（taVNS）效果的影响。TMS测量包括静息运动阈值（RMT）、无条件单脉冲TMS（spTMS）后的运动诱发电位（MEP）幅度以及短间隔皮质内抑制（SICI）和皮质内易化（ICF）的配对脉冲TMS测量，在不同的访视中进行了两次评估。评估了重测信度，并计算了经皮耳迷走神经刺激后TMS测量的变化。

结果

干预前TMS测量显示CIPN组和DN组之间的差异小于中等大小。该研究发现TMS测量具有良好的重测信度，所有感兴趣的TMS测量的组内相关系数（ICC）值在0.69至0.95之间。

讨论

总体而言，TMS测量在这个患有PN的黑人和西班牙裔/拉丁裔个体样本中显示出良好的信度，这些发现为未来旨在确定TMS测量在PN中的心理测量特性和诊断效用的研究提供了有价值的初步数据。

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