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Microsatellite instability (MSI) and the tumor mutation burden (TMB) as biomarkers of response to immune checkpoint inhibitors in prostate cancer.

作者信息

Voutsadakis Ioannis A

机构信息

Algoma District Cancer Program, Sault Area Hospital, Sault Ste Marie, Canada.

Division of Clinical Sciences, Section of Internal Medicine, Northern Ontario School of Medicine, Sudbury, Canada.

出版信息

Transl Cancer Res. 2025 May 30;14(5):2553-2557. doi: 10.21037/tcr-2024-2516. Epub 2025 May 12.

DOI:10.21037/tcr-2024-2516
PMID:40530111
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12170210/
Abstract
摘要

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Lynch syndrome-associated and sporadic microsatellite unstable colorectal cancers: different patterns of clonal evolution yield highly similar tumours.林奇综合征相关与散发性微卫星不稳定结直肠癌：不同的克隆进化模式产生高度相似的肿瘤。
Hum Mol Genet. 2024 Nov 5;33(21):1858-1872. doi: 10.1093/hmg/ddae124.
2
The Landscape and Prognosis of Microsatellite Stable (MSS) Esophageal, Gastro-Esophageal Junction and Gastric Adenocarcinomas with High Tumor Mutation Burden (TMB).具有高肿瘤突变负担（TMB）的微卫星稳定（MSS）食管、胃食管交界处和胃腺癌的全景与预后。
Cancer Invest. 2024 Sep;42(8):697-709. doi: 10.1080/07357907.2024.2388107. Epub 2024 Aug 8.
3
Target-Driven Tissue-Agnostic Drug Approvals-A New Path of Drug Development.
靶向驱动的组织非特异性药物批准——药物研发的新途径。
Cancers (Basel). 2024 Jul 13;16(14):2529. doi: 10.3390/cancers16142529.
4
Microsatellite Instability, Tumor Mutational Burden, and Response to Immune Checkpoint Blockade in Patients with Prostate Cancer.前列腺癌患者的微卫星不稳定性、肿瘤突变负担与免疫检查点阻断治疗反应
Clin Cancer Res. 2024 Sep 3;30(17):3894-3903. doi: 10.1158/1078-0432.CCR-23-3403.
5
The mutagenic consequences of defective DNA repair.DNA 修复缺陷的致突变后果。
DNA Repair (Amst). 2024 Jul;139:103694. doi: 10.1016/j.dnarep.2024.103694. Epub 2024 May 18.
6
Tumor mutational burden in colorectal cancer: Implications for treatment.结直肠癌的肿瘤突变负担：治疗意义。
Crit Rev Oncol Hematol. 2024 May;197:104342. doi: 10.1016/j.critrevonc.2024.104342. Epub 2024 Apr 12.
7
Neo-adjuvant therapies for ER positive/HER2 negative breast cancers: from chemotherapy to hormonal therapy, CDK inhibitors, and beyond.雌激素受体阳性/人表皮生长因子受体2阴性乳腺癌的新辅助治疗：从化疗到激素治疗、细胞周期蛋白依赖性激酶抑制剂及其他。
Expert Rev Anticancer Ther. 2024 Mar-Apr;24(3-4):117-135. doi: 10.1080/14737140.2024.2330601. Epub 2024 Mar 18.
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Cancer Treat Res Commun. 2023;36:100746. doi: 10.1016/j.ctarc.2023.100746. Epub 2023 Jul 22.
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Expert Opin Biol Ther. 2023 Jul-Dec;23(7):595-601. doi: 10.1080/14712598.2023.2226327. Epub 2023 Jun 18.