用于治疗宫颈癌前病变的“启动与拉动”疫苗接种策略：尚未完全准备好进入黄金时代。 - Suppr

"Prime and pull" vaccination strategy for treatment of cervical pre-cancer: not quite ready for prime time.

作者信息

Cooke Katherine, Teoh Deanna G K

机构信息

Division of Gynecologic Oncology, Department of Obstetrics, Gynecology & Women's Health, University of Minnesota, Minneapolis, MN, USA.

出版信息

Transl Cancer Res. 2025 May 30;14(5):2544-2547. doi: 10.21037/tcr-2024-2615. Epub 2025 May 19.

DOI:10.21037/tcr-2024-2615

PMID:40530116

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12169979/

Abstract

摘要

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"Prime and pull" vaccination strategy for treatment of cervical pre-cancer: not quite ready for prime time.用于治疗宫颈癌前病变的“启动与拉动”疫苗接种策略：尚未完全准备好进入黄金时代。

Transl Cancer Res. 2025 May 30;14(5):2544-2547. doi: 10.21037/tcr-2024-2615. Epub 2025 May 19.

Microbiome and metabolomic changes associated with HPV clearance in women undergoing local excisional treatment for cervical intraepithelial neoplasia.接受宫颈上皮内瘤变局部切除治疗的女性中与HPV清除相关的微生物组和代谢组变化。

mSystems. 2025 Jun 17;10(6):e0051125. doi: 10.1128/msystems.00511-25. Epub 2025 May 20.

Cervical Intraepithelial Neoplasia 3 (Cervical Intraepithelial Neoplasia 3/High-Grade Squamous Intraepithelial Lesion) in Human Papillomavirus-Vaccinated Women-Results From a Tertiary Referral Center.人乳头瘤病毒疫苗接种女性的宫颈上皮内瘤变3级（宫颈上皮内瘤变3级/高级别鳞状上皮内病变）——来自三级转诊中心的结果

J Low Genit Tract Dis. 2022 Apr 1;26(2):122-126. doi: 10.1097/LGT.0000000000000653.

Role of Cyclooxygenase-2 (COX-2) Expression as a Prediction of Persistent Cervical Low Grade Squamous Intraepithelial Lesion (LSIL).环氧化酶-2（COX-2）表达在预测持续性宫颈低度鳞状上皮内病变（LSIL）中的作用。

Asian Pac J Cancer Prev. 2025 Mar 1;26(3):791-797. doi: 10.31557/APJCP.2025.26.3.791.

Evaluation of the Therapeutic Effect of Quadrivalent Human Papillomavirus (HPV) Vaccination on Cervical Intraepithelial Neoplasia Lesions.四价人乳头瘤病毒（HPV）疫苗接种对宫颈上皮内瘤变病变的治疗效果评估。

Indian J Surg Oncol. 2023 Jun;14(2):504-509. doi: 10.1007/s13193-022-01657-w. Epub 2022 Oct 1.

Pre-vaccination distribution of human papillomavirus (HPV) genotypes in women with cervical intraepithelial neoplasia grade 3 (CIN 3) lesions in Slovenia.斯洛文尼亚宫颈上皮内瘤变3级（CIN 3）病变女性中人类乳头瘤病毒（HPV）基因型的疫苗接种前分布情况。

Acta Dermatovenerol Alp Pannonica Adriat. 2009 Jun;18(2):47-52.

Efficacy of imiquimod 5% cream for persistent human papillomavirus in genital intraepithelial neoplasm.5%咪喹莫特乳膏治疗生殖器上皮内瘤变中持续性人乳头瘤病毒的疗效

Taiwan J Obstet Gynecol. 2013 Dec;52(4):475-8. doi: 10.1016/j.tjog.2013.10.004.

Cost-Effectiveness of 9-Valent HPV Vaccination for Patients Treated for High-Grade Cervical Intraepithelial Neoplasia in the UK.英国治疗高级别宫颈上皮内瘤变患者的九价 HPV 疫苗接种的成本效益分析。

JAMA Netw Open. 2024 Oct 1;7(10):e2437703. doi: 10.1001/jamanetworkopen.2024.37703.

The efficacy of human papillomavirus prophylactic vaccination after conization in preventing cervical intraepithelial neoplasia recurrence: A prospective observational study in China.宫颈锥切术后人乳头瘤病毒预防性疫苗接种对预防宫颈上皮内瘤变复发的疗效：中国的前瞻性观察研究。

Eur J Obstet Gynecol Reprod Biol. 2023 Jul;286:10-15. doi: 10.1016/j.ejogrb.2023.04.014. Epub 2023 Apr 19.

Adjuvant VACcination against HPV in surgical treatment of Cervical Intra-epithelial Neoplasia (VACCIN study) a study protocol for a randomised controlled trial.辅助 HPV 疫苗接种治疗宫颈上皮内瘤变的手术治疗（VACCIN 研究）：一项随机对照试验的研究方案。

BMC Cancer. 2020 Jun 9;20(1):539. doi: 10.1186/s12885-020-07025-7.

本文引用的文献

Update on Effects of the Prophylactic HPV Vaccines on HPV Type Prevalence and Cervical Pathology.预防性 HPV 疫苗对 HPV 型别流行率和宫颈病变影响的最新进展。

Viruses. 2024 Aug 2;16(8):1245. doi: 10.3390/v16081245.

Low methylation marker levels among human papillomavirus-vaccinated women with cervical high-grade squamous intraepithelial lesions.接种人乳头瘤病毒疫苗的宫颈高级别鳞状上皮内病变女性中低甲基化标志物水平。

Int J Cancer. 2024 Nov 1;155(9):1549-1557. doi: 10.1002/ijc.35044. Epub 2024 May 27.

Randomized Phase II Trial of Imiquimod with or without 9-Valent HPV Vaccine versus Observation in Patients with High-grade Pre-neoplastic Cervical Lesions (NCT02864147).随机、Ⅱ期临床试验：咪喹莫特联合或不联合九价 HPV 疫苗与观察治疗用于高级别宫颈病变患者（NCT02864147）。

Clin Cancer Res. 2024 May 1;30(9):1768-1777. doi: 10.1158/1078-0432.CCR-23-3639.

Prophylactic HPV vaccines in patients with HPV-associated diseases and cancer.预防性 HPV 疫苗在 HPV 相关疾病和癌症患者中的应用。

Vaccine. 2023 Oct 6;41(42):6194-6205. doi: 10.1016/j.vaccine.2023.08.047. Epub 2023 Sep 12.

The changing nature of HPV associated with high grade cervical lesions in vaccinated populations, a retrospective study of over 1700 cases in Scotland.HPV 相关的变化性质与接种疫苗人群中的高级别宫颈病变相关，对苏格兰超过 1700 例病例的回顾性研究。

Br J Cancer. 2023 Oct;129(7):1134-1141. doi: 10.1038/s41416-023-02386-9. Epub 2023 Aug 10.

Association between loop electrosurgical excision procedure and adverse pregnancy outcomes: a meta-analysis.经阴道环行电切术与不良妊娠结局的关系：一项荟萃分析。

J Matern Fetal Neonatal Med. 2023 Dec;36(1):2183769. doi: 10.1080/14767058.2023.2183769.

Topical Imiquimod Treatment of High-grade Cervical Intraepithelial Neoplasia (TOPIC-3): A Nonrandomized Multicenter Study.局部应用咪喹莫特治疗高级别宫颈上皮内瘤变（TOPIC-3）：一项非随机多中心研究。

J Immunother. 2022 Apr 1;45(3):180-186. doi: 10.1097/CJI.0000000000000414.

Topical imiquimod compared with conization to treat cervical high-grade squamous intraepithelial lesions: Multicenter, randomized controlled trial.局部应用咪喹莫特与宫颈锥切术治疗宫颈高级别鳞状上皮内病变的多中心随机对照试验

Gynecol Oncol. 2022 Apr;165(1):23-29. doi: 10.1016/j.ygyno.2022.01.033. Epub 2022 Feb 15.

Comparison of Conservative Treatment of Cervical Intraepithelial Lesions with Imiquimod with Standard Excisional Technique Using LLETZ: A Randomized Controlled Trial.咪喹莫特与使用大环状电切术（LLETZ）的标准切除技术对宫颈上皮内瘤变进行保守治疗的比较：一项随机对照试验

J Clin Med. 2021 Dec 10;10(24):5777. doi: 10.3390/jcm10245777.

Topical Imiquimod for the Treatment of High-Grade Squamous Intraepithelial Lesions of the Cervix: A Randomized Controlled Trial.咪喹莫特局部治疗宫颈高级别鳞状上皮内病变：一项随机对照试验。

Obstet Gynecol. 2021 Jun 1;137(6):1043-1053. doi: 10.1097/AOG.0000000000004384.

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"Prime and pull" vaccination strategy for treatment of cervical pre-cancer: not quite ready for prime time.

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