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"Prime and pull" vaccination strategy for treatment of cervical pre-cancer: not quite ready for prime time.

作者信息

Cooke Katherine, Teoh Deanna G K

机构信息

Division of Gynecologic Oncology, Department of Obstetrics, Gynecology & Women's Health, University of Minnesota, Minneapolis, MN, USA.

出版信息

Transl Cancer Res. 2025 May 30;14(5):2544-2547. doi: 10.21037/tcr-2024-2615. Epub 2025 May 19.

DOI:10.21037/tcr-2024-2615
PMID:40530116
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12169979/
Abstract
摘要

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本文引用的文献

1
Update on Effects of the Prophylactic HPV Vaccines on HPV Type Prevalence and Cervical Pathology.预防性 HPV 疫苗对 HPV 型别流行率和宫颈病变影响的最新进展。
Viruses. 2024 Aug 2;16(8):1245. doi: 10.3390/v16081245.
2
Low methylation marker levels among human papillomavirus-vaccinated women with cervical high-grade squamous intraepithelial lesions.接种人乳头瘤病毒疫苗的宫颈高级别鳞状上皮内病变女性中低甲基化标志物水平。
Int J Cancer. 2024 Nov 1;155(9):1549-1557. doi: 10.1002/ijc.35044. Epub 2024 May 27.
3
Randomized Phase II Trial of Imiquimod with or without 9-Valent HPV Vaccine versus Observation in Patients with High-grade Pre-neoplastic Cervical Lesions (NCT02864147).
随机、Ⅱ期临床试验：咪喹莫特联合或不联合九价 HPV 疫苗与观察治疗用于高级别宫颈病变患者（NCT02864147）。
Clin Cancer Res. 2024 May 1;30(9):1768-1777. doi: 10.1158/1078-0432.CCR-23-3639.
4
Prophylactic HPV vaccines in patients with HPV-associated diseases and cancer.预防性 HPV 疫苗在 HPV 相关疾病和癌症患者中的应用。
Vaccine. 2023 Oct 6;41(42):6194-6205. doi: 10.1016/j.vaccine.2023.08.047. Epub 2023 Sep 12.
5
The changing nature of HPV associated with high grade cervical lesions in vaccinated populations, a retrospective study of over 1700 cases in Scotland.HPV 相关的变化性质与接种疫苗人群中的高级别宫颈病变相关，对苏格兰超过 1700 例病例的回顾性研究。
Br J Cancer. 2023 Oct;129(7):1134-1141. doi: 10.1038/s41416-023-02386-9. Epub 2023 Aug 10.
6
Association between loop electrosurgical excision procedure and adverse pregnancy outcomes: a meta-analysis.经阴道环行电切术与不良妊娠结局的关系：一项荟萃分析。
J Matern Fetal Neonatal Med. 2023 Dec;36(1):2183769. doi: 10.1080/14767058.2023.2183769.
7
Topical Imiquimod Treatment of High-grade Cervical Intraepithelial Neoplasia (TOPIC-3): A Nonrandomized Multicenter Study.局部应用咪喹莫特治疗高级别宫颈上皮内瘤变（TOPIC-3）：一项非随机多中心研究。
J Immunother. 2022 Apr 1;45(3):180-186. doi: 10.1097/CJI.0000000000000414.
8
Topical imiquimod compared with conization to treat cervical high-grade squamous intraepithelial lesions: Multicenter, randomized controlled trial.局部应用咪喹莫特与宫颈锥切术治疗宫颈高级别鳞状上皮内病变的多中心随机对照试验
Gynecol Oncol. 2022 Apr;165(1):23-29. doi: 10.1016/j.ygyno.2022.01.033. Epub 2022 Feb 15.
9
Comparison of Conservative Treatment of Cervical Intraepithelial Lesions with Imiquimod with Standard Excisional Technique Using LLETZ: A Randomized Controlled Trial.咪喹莫特与使用大环状电切术（LLETZ）的标准切除技术对宫颈上皮内瘤变进行保守治疗的比较：一项随机对照试验
J Clin Med. 2021 Dec 10;10(24):5777. doi: 10.3390/jcm10245777.
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Topical Imiquimod for the Treatment of High-Grade Squamous Intraepithelial Lesions of the Cervix: A Randomized Controlled Trial.咪喹莫特局部治疗宫颈高级别鳞状上皮内病变：一项随机对照试验。
Obstet Gynecol. 2021 Jun 1;137(6):1043-1053. doi: 10.1097/AOG.0000000000004384.