Burton M A, Gray B N, Self G W, Heggie J C, Townsend P S
Cancer Res. 1985 Nov;45(11 Pt 1):5390-3.
The effects of angiotensin II on the distribution of blood flow to experimental hepatic tumors in ten rats and rabbits were examined using blood flow tracer microspheres. The ratio of arterially introduced microspheres lodging in tumor tissue compared to the surrounding normal hepatic parenchyma was measured before and after i.v. infusion of angiotensin II-inducing incremental systemic responses. A significant elevation (P less than 0.05) in this ratio was described for both rats (3.0-fold) and rabbits (3.2-fold) following the drug infusion. Ratio elevation occurred in 37 of 40 tumors examined despite the lack of a clear dose-response relationship. In addition, angiotensin II was found to significantly (P less than 0.05) increase the number of microspheres gaining arterial access to the central portions of the tumors. In terms of internal radiation therapy, these results would indicate a substantially enhanced radiation dose reaching tumor tissue after angiotensin II infusion, while relatively sparing the surrounding normal tissue.
使用血流示踪微球研究了血管紧张素II对10只大鼠和兔子实验性肝肿瘤血流分布的影响。在静脉输注血管紧张素II诱导系统性反应增强之前和之后，测量了进入肿瘤组织的动脉注射微球与周围正常肝实质中微球的比例。药物输注后，大鼠（3.0倍）和兔子（3.2倍）的该比例均显著升高（P<0.05）。尽管缺乏明确的剂量反应关系，但在检查的40个肿瘤中有37个出现比例升高。此外，发现血管紧张素II能显著（P<0.05）增加进入肿瘤中央部分的动脉微球数量。就内放射治疗而言，这些结果表明血管紧张素II输注后到达肿瘤组织的辐射剂量显著增加，而周围正常组织相对受保护。
