Verma Kanika, Pant Malvika, Paliwal Sarvesh, Dwivedi Jaya, Sharma Swapnil
Department of Pharmacy, Banasthali Vidyapith, Banasthali, India.
Department of Chemistry, Banasthali Vidyapith, Banasthali, India.
Front Pharmacol. 2021 Aug 20;12:734917. doi: 10.3389/fphar.2021.734917. eCollection 2021.
The multifaceted nature of the renin-angiotensin system (RAS) makes it versatile due to its involvement in pathogenesis of the cardiovascular disease. Angiotensin II (Ang II), a multifaceted member of RAS family is known to have various potential effects. The knowledge of this peptide has immensely ameliorated after meticulous research for decades. Several studies have evidenced angiotensin I receptor (AT R) to mediate the majority Ang II-regulated functions in the system. Functional crosstalk between AT R mediated signal transduction cascades and other signaling pathways has been recognized. The review will provide an up-to-date information and recent discoveries involved in Ang II receptor signal transduction and their functional significance in the cardiovascular system for potential translation in therapeutics. Moreover, the review also focuses on the role of stem cell-based therapies in the cardiovascular system.
肾素-血管紧张素系统（RAS）的多面性使其具有多功能性，因为它参与了心血管疾病的发病机制。血管紧张素II（Ang II）是RAS家族的一个多面成员，已知具有多种潜在作用。经过数十年的细致研究，对这种肽的了解有了极大改善。多项研究已证明血管紧张素I受体（AT R）介导该系统中大多数由Ang II调节的功能。AT R介导的信号转导级联与其他信号通路之间的功能性相互作用已得到确认。本综述将提供有关Ang II受体信号转导及其在心血管系统中的功能意义的最新信息和最新发现，以便在治疗中进行潜在转化。此外，本综述还聚焦于基于干细胞的疗法在心血管系统中的作用。
