Hafström L, Nobin A, Persson B, Sundqvist K
Cancer Res. 1980 Feb;40(2):481-5.
The effects of infusion of adrenaline and noradrenaline were studied in rats with intrahepatic tumors, using 99mTc-and 51Cr-labeled microspheres. The effect on general circulation, cardiac output, and tissue blood flow was pronounced, especially with infusion of noradrenaline. Studies of liver tumor perfusion in relation to surrounding liver parenchyma perfusion showed an increased tumor/liver ratio in noradrenaline-infused rats, thus indicating a preferential blood flow to the tumors induced by this drug. Adrenaline as well as 0.9% NaCl solution infusion had no effect on tumor/liver blood flow ratios. Fluorescence microscopy and monoamine determination could not reveal any noradrenaline containing nerves in the liver tumors. These experiments might suggest that the effect of intraarterial infusion with cytostatic agents might be enhanced by a simultaneously administered vasoconstrictor such as noradrenaline.
利用99mTc和51Cr标记的微球体，研究了肾上腺素和去甲肾上腺素输注对肝内肿瘤大鼠的影响。对全身循环、心输出量和组织血流的影响显著，尤其是在输注去甲肾上腺素时。关于肝肿瘤灌注与周围肝实质灌注关系的研究表明，输注去甲肾上腺素的大鼠肿瘤/肝脏比值增加，这表明该药物可诱导肿瘤优先血流。肾上腺素以及0.9%氯化钠溶液输注对肿瘤/肝脏血流比值没有影响。荧光显微镜检查和单胺测定未能发现肝肿瘤中有任何含去甲肾上腺素的神经。这些实验可能表明，同时给予血管收缩剂如去甲肾上腺素可能会增强动脉内输注细胞抑制剂的效果。
