Schwartz Andrew M, Deckey David G, Chun Danielle S, Seyler Thorsten M, Watters Tyler S
Department of Orthopaedic Surgery, Duke University Health System, Durham, NC.
Raleigh Orthopaedic Clinic, Raleigh, NC.
Arthroplast Today. 2025 Jun 4;33:101719. doi: 10.1016/j.artd.2025.101719. eCollection 2025 Jun.
Native knee septic arthritis due to complex (MAC) is extremely rare. Disseminated MAC infections are often associated with an immunosuppressed state; however, they can occur in immunocompetent patients. We describe a case of MAC infection in the native knee in an immunocompetent patient resulting in osseous destruction and secondary arthritic changes. Both the infection and destructive arthropathy were successfully treated with a single procedure consisting of radical debridement, primary total knee arthroplasty with high-dose pathogen-specific antibiotic therapy, and subsequent systemic antibiotic therapy. At 3.5 years since surgery, the patient is off antibiotic therapy and continues to have a well-functioning total knee arthroplasty.
由鸟分枝杆菌复合体（MAC）引起的原发性膝关节脓毒性关节炎极为罕见。播散性MAC感染通常与免疫抑制状态相关；然而，它们也可能发生在免疫功能正常的患者中。我们描述了一例免疫功能正常的患者原发性膝关节MAC感染，导致骨质破坏和继发性关节炎改变。通过一次手术成功治疗了感染和破坏性关节病，该手术包括彻底清创、高剂量病原体特异性抗生素治疗的初次全膝关节置换术以及随后的全身抗生素治疗。术后3.5年，患者停用抗生素治疗，全膝关节置换术功能良好。
