营养免疫与真菌病原体：锰的新作用
Nutritional Immunity and Fungal Pathogens: a New Role for Manganese.
作者信息
Wildeman Asia S, Culotta Valeria C
机构信息
Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health 615 N. Wolfe Street, Baltimore, MD 21205.
出版信息
Curr Clin Microbiol Rep. 2024 Jun;11(2):70-78. doi: 10.1007/s40588-024-00222-z. Epub 2024 Mar 20.
PURPOSE OF REVIEW
Copper, zinc, iron and manganese are essential micronutrients for all living organisms. Microbial pathogens must acquire these elements from their host. Through a process termed nutritional immunity, animal hosts seek to withhold these vital nutrients from the microbe and the competition for metals can influence survival outcomes during infection. Much is known about the battle for iron, copper and zinc during fungal infections, but a picture is just now beginning to emerge for manganese.
RECENT FINDINGS
Pathogenic fungi utilize manganese for antioxidant defense, cell wall construction, morphogenesis and survival in animal and plant hosts. The animal host can limit manganese availability for invading fungi at the macrophage, neutrophil and whole tissue levels.
综述目的
铜、锌、铁和锰是所有生物必需的微量营养素。微生物病原体必须从宿主获取这些元素。通过一种称为营养免疫的过程，动物宿主试图阻止这些重要营养素进入微生物体内，而对金属的竞争会影响感染期间的生存结果。关于真菌感染期间铁、铜和锌的争夺已有很多了解，但锰的情况才刚刚开始显现。
最新发现
致病真菌利用锰进行抗氧化防御、细胞壁构建、形态发生以及在动植物宿主中生存。动物宿主可在巨噬细胞、中性粒细胞和全组织水平限制入侵真菌获取锰的能力。
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