Chen C J, Chuang Y C, Lin T M, Wu H Y
Cancer Res. 1985 Nov;45(11 Pt 2):5895-9.
The objective of this study is to elucidate the association between high-arsenic artesian well water and cancers in endemic area of blackfoot disease, a unique peripheral vascular disease related to continuous arsenic exposure. As compared with the general population in Taiwan, both the standardized mortality ratio (SMR) and cumulative mortality rate were significantly high in blackfoot disease-endemic areas for cancers of bladder, kidney, skin, lung, liver, and colon. The SMRs for cancers of bladder, kidney, skin, lung, liver, and colon were 1100, 772, 534, 320, 170, and 160, respectively, for males, and 2009, 1119, 652, 413, 229, and 168, respectively, for females. A dose-response relationship was observed between SMRs of the cancers and blackfoot disease prevalence rate of the villages and townships in the endemic areas. SMRs of cancers were greater in villages where only artesian wells were used as the drinking water source than in villages using both artesian and shallow wells, and even greater than in villages using shallow wells only.
本研究的目的是阐明在与持续砷暴露相关的独特外周血管疾病——黑脚病流行地区，高砷自流井水与癌症之间的关联。与台湾一般人群相比，黑脚病流行地区膀胱、肾、皮肤、肺、肝和结肠癌症的标准化死亡率（SMR）和累积死亡率均显著较高。男性膀胱、肾、皮肤、肺、肝和结肠癌的SMR分别为1100、772、534、320、170和160，女性分别为2009、1119、652、413、229和168。在流行地区，癌症的SMR与乡镇黑脚病患病率之间存在剂量反应关系。仅将自流井水用作饮用水源的村庄中癌症的SMR高于同时使用自流井和浅井的村庄，甚至高于仅使用浅井的村庄。
