Department of Environmental Health Engineering, School of Public Health, Research Centre for Health Sciences, Hamadan University of Medical Sciences, Hamadan, Iran.
Department of Epidemiology, School of Public Health, Research Center for Health Sciences, Hamadan University of Medical Sciences, Hamadan, Iran.
Sci Rep. 2023 Sep 19;13(1):15456. doi: 10.1038/s41598-023-42744-4.
The present study aims to determine the relationship between the concentration of arsenic in the groundwater of Hamadan province and the mortality rate due to various types of malignancies, congenital anomalies, diabetes mellitus and Alzheimer's. Mortality data due to various causes of death in Hamadan province were collected for five years (2016-2020). Sampling of drinking water was determined in the reference laboratory using polarography method. Poisson regression was used to investigate the relationship between arsenic level and the death rate due to various types of disease, at a significant level (p value < 0.05). According to the results of Poisson regression, among the various causes of death (N = 8042), Alzheimer's 5.94 (3.67-9.61), diabetes mellitus 4.05 (3.5-5.37), congenital malformations 2.98 (1.88-4.72), breast cancer 2.72 (1.56-4.71), leukemia 1.90 (1.24-2.92), stomach cancer 1.64 (1.28-2.10), Liver cancer 1.58 (1.58-2.30), other digestive organs 5.86 (3.38-10.16), meninges and brain cancer 1.57 (1.02-2.41) showed the highest relationship with arsenic contamination. The results of this study could be evidence for a positive and significant relationship between arsenic concentrations and mortality rates due to cancers, diabetes mellitus, Alzheimer disease, and congenital malformations. Therefore, it's necessary to use appropriate water treatment methods to remove arsenic at the source in contaminated areas.
本研究旨在确定伊朗哈马丹省地下水砷浓度与各种类型恶性肿瘤、先天畸形、糖尿病和阿尔茨海默病死亡率之间的关系。收集了哈马丹省五年（2016-2020 年）的各种死因死亡率数据。在参考实验室中使用极谱法确定饮用水采样。采用泊松回归分析方法，在显著水平（p 值 < 0.05）下，研究了砷水平与各种疾病死亡率之间的关系。根据泊松回归的结果，在各种死因（N=8042）中，阿尔茨海默病 5.94（3.67-9.61）、糖尿病 4.05（3.5-5.37）、先天畸形 2.98（1.88-4.72）、乳腺癌 2.72（1.56-4.71）、白血病 1.90（1.24-2.92）、胃癌 1.64（1.28-2.10）、肝癌 1.58（1.58-2.30）、其他消化系统器官 5.86（3.38-10.16）、脑膜和脑癌 1.57（1.02-2.41）与砷污染的关系最为密切。本研究的结果可为砷浓度与癌症、糖尿病、阿尔茨海默病和先天畸形死亡率之间存在正相关关系提供证据。因此，有必要在污染地区从源头采用适当的水处理方法去除砷。
