Daraghmeh Dala N, Salameh Sawsan, Zahdeh Massa, Ghanem Rania, Karaman Rafik
Pharmaceutical Sciences Department, Faculty of Pharmacy, Al-Quds University, P.O. Box 20002, Jerusalem, Palestine.
Curr Drug Metab. 2025 Jun 16. doi: 10.2174/0113892002357565250604075932.
The female reproductive system is susceptible to oxidative stress, which can interfere with ovulation, menstrual cycles, egg quality, and tubal function, ultimately leading to infertility. Antioxidants might play a crucial role in protecting reproductive health by neutralizing Reactive Oxygen Species (ROS) and preventing cellular damage.
To provide an overview of the research that has been performed on the benefits of antioxidant supplementation for increasing female fertility.
We conducted a comprehensive search of PubMed, Embase, and Google for full-text, English-lan-guage publications between 2000 and 2023 that investigated the relationship between antioxidant supplemen-tation and improvements in female fertility.
Antioxidants have been investigated for their potential to improve fertility outcomes in subfertile women. Antioxidant supplementation shows promise in mitigating these effects by neutralizing excess ROS and restoring balance, leading to improved egg count and fertility outcomes. However, it is important to note that the effectiveness of antioxidant supplementation can vary depending on individual health factors and the specific antioxidants used. Studies suggest that a combination of antioxidants, such as vitamins C and E, se-lenium, and coenzyme Q10, may be more beneficial than single supplements. Although individual research has shown beneficial correlations between different antioxidant supplementation and female fertility, study repeatability is poor. As a result, further large-scale, well-designed clinical trials are necessary to better un-derstand the precise role and optimal combinations of antioxidants for enhancing fertility in subfertile women.
This review study offers crucial insights into the complex connection between OS and female reproductive health. It highlights the potential advantages of antioxidant supplements as a preventative strat-egy. To enhance female fertility outcomes, further research, particularly randomized controlled clinical trials, is needed to determine best practices, identify populations that could benefit the most, and explore innovative antioxidant treatments.
女性生殖系统易受氧化应激影响，氧化应激会干扰排卵、月经周期、卵子质量和输卵管功能，最终导致不孕。抗氧化剂可能通过中和活性氧（ROS）和防止细胞损伤，在保护生殖健康方面发挥关键作用。
概述关于补充抗氧化剂对提高女性生育能力益处的研究。
我们对PubMed、Embase和谷歌进行了全面检索，以查找2000年至2023年间研究补充抗氧化剂与改善女性生育能力之间关系的英文全文出版物。
已对抗氧化剂改善亚生育女性生育结局的潜力进行了研究。补充抗氧化剂有望通过中和过量ROS并恢复平衡来减轻这些影响，从而增加卵子数量并改善生育结局。然而，需要注意的是，补充抗氧化剂的有效性可能因个体健康因素和所使用的特定抗氧化剂而异。研究表明，维生素C和E、硒和辅酶Q10等抗氧化剂组合可能比单一补充剂更有益。尽管个别研究表明不同的抗氧化剂补充与女性生育能力之间存在有益关联，但研究的可重复性较差。因此，需要进一步开展大规模、设计良好的临床试验，以更好地了解抗氧化剂在提高亚生育女性生育能力方面的确切作用和最佳组合。
本综述研究为氧化应激与女性生殖健康之间的复杂联系提供了重要见解。它强调了抗氧化剂补充剂作为一种预防策略的潜在优势。为了改善女性生育结局，需要进一步研究，特别是随机对照临床试验，以确定最佳实践方法，确定最能受益的人群，并探索创新的抗氧化剂治疗方法。
