Koyama Eiji, Tobita Kazuki, Sawada Shun, Kai Motoaki, Mityashita Hirokazu, Saito Shigeru
Department of Cardiology, Shonan Kamakura General Hospital, 1370-1 Okamoto, Kanagawa, Kamakura, 247-8533, Japan.
CVIR Endovasc. 2025 Jun 18;8(1):53. doi: 10.1186/s42155-025-00568-5.
Persistent sciatic artery (PSA) is a rare congenital anomaly associated with various complications, including atherosclerotic changes and aneurysms. These changes can cause limb ischemia, thrombosis, distal embolization of the PSA, rupture of aneurysms, buttock pain, and sciatica due to compression of adjacent tissues. Acute limb ischemia (ALI) is a life-threatening condition. Treatment of ALI includes surgical and endovascular treatments (EVT); EVT includes catheter-directed thrombolysis (CDT) and angioplasty, with thrombolysis being highly effective. In Japan, urokinase is the only insurance-covered thrombolytic agent approved for ALI treatment; however, it is currently unavailable due to manufacturing issues.
This case report details the treatment of two women (aged 89 and 82 years) with ALI associated with PSA. In both cases, reperfusion was achieved without CDT and stent grafts were deployed across the PSA aneurysm. The final angiogram showed that the PSA aneurysms had disappeared, and the vessel runoff was maintained. Both patients were successfully discharged from the hospital and experienced no complications over the next 6 months.
Two patients with ALI with PSA were treated with EVT without CDT. These cases suggest that EVT without CDT may rescue ALI caused by PSA. Moreover, no standard treatment for sciatic artery remnants has been established. Endovascular treatment with stent grafts may be an option for older patients.
持续性坐骨动脉(PSA)是一种罕见的先天性异常,与多种并发症相关,包括动脉粥样硬化改变和动脉瘤。这些改变可导致肢体缺血、血栓形成、PSA远端栓塞、动脉瘤破裂、臀部疼痛以及因邻近组织受压引起的坐骨神经痛。急性肢体缺血(ALI)是一种危及生命的疾病。ALI的治疗包括手术和血管内治疗(EVT);EVT包括导管定向溶栓(CDT)和血管成形术,溶栓非常有效。在日本,尿激酶是唯一被批准用于ALI治疗的医保覆盖溶栓剂;然而,由于生产问题,目前无法获得。
本病例报告详细介绍了两名患有与PSA相关的ALI的女性(分别为89岁和82岁)的治疗情况。在这两个病例中,未进行CDT就实现了再灌注,并在PSA动脉瘤处植入了支架移植物。最终血管造影显示PSA动脉瘤消失,血管血流得以维持。两名患者均成功出院,在接下来的6个月内未出现并发症。
两名患有与PSA相关的ALI的患者接受了无CDT的EVT治疗。这些病例表明,无CDT的EVT可能挽救由PSA引起的ALI。此外,尚未确立坐骨动脉残余的标准治疗方法。对于老年患者,血管内植入支架移植物治疗可能是一种选择。