Stockley R A, Hill S L, Burnett D
Clin Ther. 1985;7(5):593-9.
Nebulized amoxicillin (500 mg twice a day) was given for four months to six patients with bronchiectasis. The patients had continually produced purulent secretions, which had failed to clear (purulent to mucoid) when amoxicillin was given orally (3 gm twice a day). All patients found the nebulization technique acceptable, and no acute effect on lung function was seen. There were significant reductions in sputum purulence (P less than 0.025) and volume (P less than 0.05) and a mean (+/- SD) increase in peak expired flow rate (P less than 0.05) from 230.5 +/- 79.2 L/min to 255 +/- 90.1 L/min. These improvements occurred despite the fact that apparently resistant bacteria were cultured. No adverse effects were noted. The response to nebulized amoxicillin after failure with the same drug given orally suggests that local concentrations of antibiotic in the lungs of these patients is important.
对6例支气管扩张患者雾化吸入阿莫西林（500毫克，每日两次），持续四个月。这些患者持续咳出脓性分泌物，口服阿莫西林（3克，每日两次）时脓性分泌物未能清除（从脓性变为黏液性）。所有患者均认为雾化技术可接受，且未观察到对肺功能的急性影响。痰的脓性程度（P<0.025）和量（P<0.05）显著降低，呼气峰值流速平均（±标准差）增加（P<0.05），从230.5±79.2升/分钟增至255±90.1升/分钟。尽管培养出明显耐药的细菌，但仍出现了这些改善。未观察到不良反应。口服相同药物治疗失败后对雾化吸入阿莫西林的反应表明，这些患者肺部抗生素的局部浓度很重要。
