Manshd Abbas Ali, Alaboudi Mohammed Ali, Al-Raad Abbas Abdulameer
Sawa University, College of Health and Medical Technology, Department of Medical Laboratories - Al-Muthanna, Iraq.
Al-Muthanna University, College of Education for Pure Sciences, Department of Biology - Al-Muthanna, Iraq.
Rev Assoc Med Bras (1992). 2025 Jun 16;71(5):e20241860. doi: 10.1590/1806-9282.20241860. eCollection 2025.
The failure to conceive following 12 months of unprotected intercourse is referred to as infertility. About 35% of the instances include women and 30% involve men.
The aim of this study was to investigate the gene polymorphisms FASL-844C/T and FAS-670A/G in the promoter region to evaluate susceptibility to male infertility.
We have investigated single-nucleotide polymorphisms of FAS-670A/G gene and FASL-844C/T gene in 100 subjects. A total of 50 male patients with infertility constituted the infertility group and another group consisting of 50 apparently healthy individuals comprised the control group.
The prevalence rate of FAS-670A/G gene polymorphism was statistically significant among both azoospermia and oligospermia subgroups, the homozygous mutant genotype GG (p=0.014 and p=0.043), and mutant allele G (p=0.001 and p=0.004), respectively. Also, FASL-844C/T gene polymorphism was statistically significant among both azoospermia and oligospermia subgroups, the homozygous mutant genotype TT (p=0.032 and p=0.032), and mutant allele T (p=0.007 and p=0.002), respectively.
FAS homozygous mutant genotype (GG) and FASL homozygous mutant genotype (TT) act as etiologic factors in male infertility.
未采取避孕措施性交12个月后仍未能受孕被称为不孕症。约35%的病例涉及女性，30%涉及男性。
本研究旨在调查启动子区域的FASL - 844C/T和FAS - 670A/G基因多态性，以评估男性不育的易感性。
我们调查了100名受试者的FAS - 670A/G基因和FASL - 844C/T基因的单核苷酸多态性。50名男性不育患者组成不育组，另一组由50名明显健康的个体组成对照组。
FAS - 670A/G基因多态性在无精子症和少精子症亚组中的患病率具有统计学意义，纯合突变基因型GG（p = 0.014和p = 0.043）以及突变等位基因G（p = 0.001和p = 0.004）。此外，FASL - 844C/T基因多态性在无精子症和少精子症亚组中也具有统计学意义，纯合突变基因型TT（p = 0.032和p = 0.032）以及突变等位基因T（p = 0.007和p = 0.002）。
FAS纯合突变基因型（GG）和FASL纯合突变基因型（TT）是男性不育的病因。
