Mazzoni A, Fiorentini C, Cevenini R, Nanetti A
Chemioterapia. 1985 Aug;4(4):299-302.
Serum ketoconazole levels in leukemic patients, subjected to ketoconazole prophylaxis, were determined by an agar diffusion assay. High individual variability of drug concentration was noted. In addition, the highest drug concentration observed was less than 1 microgram/ml in 5 out of 6 patients studied. The reliability of prophylaxis of airborne opportunistic fungal infections by ketoconazole seems, therefore, to be hampered, at least in leukemics, by the too low serum concentrations of the drug. The bioassay proved to be highly reproducible and accurate as well as easy and safe to perform.
通过琼脂扩散试验测定了接受酮康唑预防治疗的白血病患者的血清酮康唑水平。发现药物浓度存在高度个体差异。此外，在所研究的6名患者中，有5名患者观察到的最高药物浓度低于1微克/毫升。因此，至少在白血病患者中，酮康唑预防空气传播的机会性真菌感染的可靠性似乎受到药物血清浓度过低的阻碍。生物测定法被证明具有高度可重复性、准确性，且操作简便、安全。
