Moreno-Celis Ulisses, Aguilar-Galarza Adriana, García-Gasca Teresa
Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Querétaro, Querétaro México.
Gac Med Mex. 2025;161(1):85-93. doi: 10.24875/GMM.M25000984.
This paper addresses the genetic influence on obesity within the Mexican population, highlighting that this condition is the result of a complex interaction between genetic and environmental factors. Specific genetic variants are identified that not only predispose to obesity but may also offer protection against it. This knowledge is crucial for the development of personalized medicine and nutrition strategies that adapt health interventions to the individual genetic characteristics of patients, thus improving the effectiveness in the prevention and treatment of obesity. Despite the promising potential of personalized medicine and nutrition, the study recognizes significant challenges, such as genetic variability within the Mexican population, the infrastructure necessary to integrate genetic data into clinical practice, and ethical considerations in the management of this information. It is important to highlight the need for future research that delves deeper into the relationship between genetics and obesity, also considering environmental factors. Likewise, it is suggested that the integration of these findings into public health policies could offer more specific and effective approaches to combat obesity in Mexico, contributing significantly to improving health in the population.
本文探讨了墨西哥人群中基因对肥胖的影响,强调这种状况是基因和环境因素复杂相互作用的结果。已确定了特定的基因变体,这些变体不仅使人易患肥胖症,还可能提供预防肥胖的保护作用。这些知识对于开发个性化医疗和营养策略至关重要,这些策略可根据患者的个体基因特征调整健康干预措施,从而提高肥胖预防和治疗的效果。尽管个性化医疗和营养具有广阔前景,但该研究认识到存在重大挑战,如墨西哥人群中的基因变异性、将基因数据整合到临床实践所需的基础设施以及管理此类信息时的伦理考量。必须强调未来研究的必要性,即更深入地探究基因与肥胖之间的关系,同时也要考虑环境因素。同样,建议将这些研究结果纳入公共卫生政策,可为墨西哥对抗肥胖提供更具体、有效的方法,对改善民众健康做出重大贡献。