用苯丁酸氮芥治疗的葡萄膜炎患者的长期细胞遗传学随访研究。

Long-term cytogenetic follow-up study of patients with uveitis treated with chlorambucil.

作者信息

Reeves B R, Casey G, Harris H, Dinning W J

出版信息

Carcinogenesis. 1985 Nov;6(11):1615-9. doi: 10.1093/carcin/6.11.1615.

DOI:10.1093/carcin/6.11.1615

Abstract

We have studied the long-term effects of chlorambucil treatment on the chromosomes of peripheral blood lymphocytes from patients with uveitis. Amounts of chromosome damage (breaks and rearrangements) were found to vary between individuals, but tended to increase with the cumulative dose. Some patients were found to have persistently high levels of chromosome damage many years after treatment had been completed.

摘要

我们研究了苯丁酸氮芥治疗对葡萄膜炎患者外周血淋巴细胞染色体的长期影响。发现染色体损伤（断裂和重排）的程度在个体之间存在差异，但往往随着累积剂量的增加而增加。一些患者在治疗结束多年后仍有持续高水平的染色体损伤。