Palmer R G, Varonos S, Doré C J, Denman A M, Ansell B M
Arch Dis Child. 1985 Nov;60(11):1008-13. doi: 10.1136/adc.60.11.1008.
Sister chromatid exchanges, a sensitive measure of chromosome damage, were counted in peripheral blood lymphocytes from 23 patients with juvenile chronic arthritis receiving long term, low dose chlorambucil treatment. Thirty five patients with juvenile chronic arthritis who had not been treated with cytotoxic drugs served as controls. All of the treated patients have cells with abnormal sister chromatid exchange frequencies. Damage is related to the daily dose and may, in part, be determined by the duration of treatment. Sister chromatid exchanges from nine patients who had received chlorambucil at some time in the past remained high for at least five months after stopping the drug. Long term follow up will determine whether sister chromatid exchange analysis can help predict those most at risk of drug induced malignancies.
对23名接受长期低剂量苯丁酸氮芥治疗的青少年慢性关节炎患者的外周血淋巴细胞进行姐妹染色单体交换计数，这是一种检测染色体损伤的敏感方法。35名未接受细胞毒性药物治疗的青少年慢性关节炎患者作为对照。所有接受治疗的患者都有姐妹染色单体交换频率异常的细胞。损伤与每日剂量有关，且部分可能由治疗持续时间决定。9名过去曾接受过苯丁酸氮芥治疗的患者，在停药后至少五个月内姐妹染色单体交换率仍维持在较高水平。长期随访将确定姐妹染色单体交换分析是否有助于预测那些最易发生药物诱导性恶性肿瘤的患者。
