Roveta Annalisa, Canonico Massimo, Francese Alessia, Sarchi Eleonora, Ugo Francesca, Massarino Costanza, Penpa Serena, Piceni Giorgia, Barrera-León Luisa, Apeddu Alessandro, Picozzi Emanuele, Chichino Guido, Maconi Antonio
Research Laboratories, Research and Innovation Department (DAIRI), Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
Integrated Laboratory of AI and Informatics in Medicine, DAIRI, Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e Cesare Arrigo, and DISIT- University of Piemonte Orientale, Alessandria, Italy.
Appl Clin Inform. 2025 May;16(3):544-555. doi: 10.1055/a-2543-7444. Epub 2025 Jun 18.
Human immunodeficiency virus (HIV) remains a significant global health challenge, especially in Europe, including Italy, where it affects thousands. Antiretroviral therapy (ART) has turned HIV into a manageable chronic condition, improving the quality of life and life expectancy for people living with HIV (PLWH). Enhancing health-related quality of life (HRQoL) is essential, as it positively influences therapy adherence.The objective of the study was to evaluate the impact of the AURORA system, a self-monitoring tool designed for HIV+ patients, on their quality of life and healthcare management. We aimed to assess specific aspects of well-being, including sleep quality, depression, and anxiety disorders, while also measuring patient satisfaction with the application and adherence to ART.Fifty HIV+ patients on a stable antiretroviral regimen for at least 6 months were recruited from the Infectious Diseases Department of AOU-AL and asked to download a health monitoring app. ART adherence, HRQoL, and project satisfaction were assessed through patient self-reports.A total of 50 virologically suppressed HIV+ patients were enrolled in the study, of whom eight were non-compliant with the protocol. The AURORA app was used from June 2023 to March 2024, demonstrating optimal adherence to therapy among compliant patients. A significant proportion (26.2%) reported that they found the app very beneficial, while less than 5% reported no benefit at all. Common feedback included the inability to modify certain notification settings. The results indicated significant correlations between sleep disturbances, anxiety, and depression. Patients liked the daily assessment of self-care, synchronously monitored by clinicians, and guaranteed privacy, but several improvements need to be made.Participant feedback will guide app enhancements, such as phone call integration, health data monitoring, and e-learning features to improve patient-clinician communication and personalized education. Future directions may include extending the project and adding a control group not using the app, allowing a comparison of therapy adherence and patient satisfaction between users and non-users. This would provide concrete data on the app's effectiveness in promoting therapy compliance.
人类免疫缺陷病毒（HIV）仍然是一项重大的全球健康挑战，尤其是在包括意大利在内的欧洲，该国数千人受到影响。抗逆转录病毒疗法（ART）已将HIV转变为一种可控制的慢性病，提高了HIV感染者（PLWH）的生活质量和预期寿命。提高与健康相关的生活质量（HRQoL）至关重要，因为它对治疗依从性有积极影响。本研究的目的是评估专为HIV阳性患者设计的自我监测工具AURORA系统对其生活质量和医疗管理的影响。我们旨在评估幸福感的具体方面，包括睡眠质量、抑郁和焦虑症，同时还测量患者对该应用程序的满意度以及对ART的依从性。从AOU-AL传染病科招募了50名接受稳定抗逆转录病毒治疗至少6个月的HIV阳性患者，并要求他们下载一款健康监测应用程序。通过患者自我报告评估ART依从性、HRQoL和项目满意度。共有50名病毒学抑制的HIV阳性患者参与了该研究，其中8名不符合研究方案。AURORA应用程序于2023年6月至2024年3月使用，显示出依从患者对治疗的最佳依从性。很大一部分（26.2%）报告称他们发现该应用程序非常有益，而不到5%的人报告完全没有益处。常见的反馈包括无法修改某些通知设置。结果表明睡眠障碍、焦虑和抑郁之间存在显著相关性。患者喜欢由临床医生同步监测的每日自我护理评估以及保证的隐私，但仍需要进行一些改进。参与者的反馈将指导应用程序的改进，例如电话集成、健康数据监测和电子学习功能，以改善患者与临床医生的沟通和个性化教育。未来的方向可能包括扩展该项目并增加一个不使用该应用程序的对照组，以便比较使用者和非使用者之间的治疗依从性和患者满意度。这将提供关于该应用程序在促进治疗依从性方面有效性的具体数据。
