Teshima Takahiro, Nagashima Tomokazu, Yasumura Yuyo, Yasuda Akiko, Miyagawa Yuichi, Michishita Masaki, Suzuki Ryohei, Matsumoto Hirotaka
Laboratory of Veterinary Internal Medicine, School of Veterinary Medicine, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, Tokyo, Japan.
Research Center for Animal Life Science, Nippon Veterinary and Life Science University, Tokyo, Japan.
J Vet Med Sci. 2025 Aug 1;87(8):876-880. doi: 10.1292/jvms.25-0112. Epub 2025 Jun 17.
A 12-year-old castrated male Labrador Retriever presented with asymptomatic hypercalcemia. Based on elevated parathyroid hormone levels and an enlarged parathyroid gland, primary hyperparathyroidism was suspected, and parathyroidectomy was performed, but the hypercalcemia did not improve. Histopathology of three resected parathyroid glands revealed hyperplasia and hypertrophy of the principal cells. After surgery, the fractional excretion of calcium examined in a spot urine sample was close to that in healthy dogs, but lower than that in a dog with primary hyperparathyroidism. Autoantibodies against calcium-sensing receptor (CaSR) were confirmed by incubating a cell line expressing canine CaSR with a serum sample from the hypercalcemic dog. Our report is the first to describe the diagnosis of acquired hypocalciuric hypercalcemia in a dog.
一只12岁去势雄性拉布拉多猎犬出现无症状性高钙血症。基于甲状旁腺激素水平升高和甲状旁腺肿大，怀疑为原发性甲状旁腺功能亢进，并进行了甲状旁腺切除术，但高钙血症并未改善。对三个切除的甲状旁腺进行组织病理学检查，发现主细胞增生和肥大。术后，对一份随机尿样中钙的排泄分数进行检测，结果接近健康犬，但低于原发性甲状旁腺功能亢进犬。通过将表达犬钙敏感受体（CaSR）的细胞系与高钙血症犬的血清样本孵育，证实了针对CaSR的自身抗体。我们的报告首次描述了犬获得性低钙尿性高钙血症的诊断。
