Kamal Wafaa M, Maged Ahmed M, Salah Noha, El-Goly Nour A, El-Sherbiny Wael, Hassan Elham S
Department of Physical Therapy for Woman's Health, Faculty of Physical Therapy, Benha University, Benha, Egypt.
Department of Obstetrics and Gynecology, Kasr Al-Ainy Hospital, Cairo University, Cairo, Egypt.
Obstet Gynecol Sci. 2025 Jul;68(4):334-343. doi: 10.5468/ogs.25077. Epub 2025 Jun 19.
This study aimed to evaluate the effects of narrowband ultraviolet B (UVB) irradiation on bone and muscle health in postmenopausal women.
A randomized controlled trial was conducted involving 70 postmenopausal women with vitamin D deficiency (<20 ng/mL) and osteopenia. Participants were randomly assigned to two groups. For 6 months, 35 postmenopausal women in study group A received three weekly sessions of narrowband UVB therapy and vitamin D supplements in the form of 100,000 international unit (IU) cholecalciferol weekly as loading therapy for 8 weeks. This was followed by the daily administration of cholecalciferol 3,000 IU as maintenance therapy for 16 weeks. The control group B consisted of 35 postmenopausal women who were administered vitamin D supplements alone for 6 months. Enzyme-linked immuno sorbent assay kits were used to test the serum levels of 25-hydroxyvitamin D (25(OH)D), dual-energy X-ray absorptiometry (DEXA) (DMS, Occitanie, France) was used to test the bone mineral density of the lumbar spine and right femur, and a Biodex System 3 (Biodex Medical Systems Inc., Shirley, NY, USA) isokinetic dynamometer was used to assess the peak torque of the extensors and flexors of the dominant knee.
Serum 25(OH)D levels (P=0.000), Lumbar T-score (P=0.008), femoral T-score (P=0.002), and knee extensor peak torque (P=0.030) significantly increased in both groups after 6 months of treatment, favoring study group A over the control group B.
Narrowband UVB combined with vitamin D3 supplementation is more effective than vitamin D supplementation alone.
本研究旨在评估窄谱中波紫外线（UVB）照射对绝经后女性骨骼和肌肉健康的影响。
进行了一项随机对照试验，纳入70名维生素D缺乏（<20 ng/mL）且患有骨质减少的绝经后女性。参与者被随机分为两组。6个月内，研究组A的35名绝经后女性接受每周3次的窄谱UVB治疗，并以每周100,000国际单位（IU）胆钙化醇的形式补充维生素D作为8周的负荷治疗。之后，每日服用3,000 IU胆钙化醇作为维持治疗16周。对照组B由35名绝经后女性组成，她们仅接受6个月的维生素D补充。使用酶联免疫吸附测定试剂盒检测血清25-羟基维生素D（25(OH)D）水平，采用双能X线吸收法（DEXA）（法国奥克西塔尼的DMS）检测腰椎和右股骨的骨密度，使用美国纽约雪莉市Biodex Medical Systems Inc.的Biodex System 3等速测力计评估优势膝关节伸肌和屈肌的峰值扭矩。
治疗6个月后，两组的血清25(OH)D水平（P = 0.000）、腰椎T值（P = 0.008）、股骨T值（P = 0.002）和膝关节伸肌峰值扭矩（P = 0.030）均显著升高，研究组A优于对照组B。
窄谱UVB联合补充维生素D3比单独补充维生素D更有效。
