Department of Nutrition and Epidemiology, Medical University of Lodz, Poland.
Department of Endocrine Disorders and Bone Metabolism, Medical University of Lodz, Poland.
Adv Clin Exp Med. 2022 Jan;31(1):25-32. doi: 10.17219/acem/141604.
In Europe, the rate of 25(OH)D deficiency is considered high. Thus, it seems necessary to conduct population-based studies to fully assess vitamin D deficiency in various groups of patients.
To evaluate serum 25(OH)D levels and the frequency of deficiency in women in Poland with endocrine and osteoporotic disorders. The influences of diet, use of vitamin/mineral supplementation and exposure to ultraviolet (UVB) radiation on vitamin D status in women with metabolic disorders were also examined.
The patient group consisted of 223 women aged 19-81 years diagnosed with endocrine and/or osteoporotic disorders. The control group consisted of 108 clinically healthy women aged 26-72 years. Serum 25(OH)D concentration was assessed using a chemiluminescent immunoassay (CLIA). An ad hoc questionnaire was used to assess the participants' exposure to UVB radiation. Food intake was assessed using a three-day 24-hour questionnaire interview.
The following groups showed significantly higher 25(OH)D levels: women taking vitamin D supplements compared to women not taking vitamin D supplements (29.3 ±3.2 compared to 19.5 ±3.7 ng/mL, p = 0.0024); premenopausal women compared to postmenopausal women (28.9 ±5.2 compared to 21.5 ±4.5 ng/mL, p = 0.0021); women who visited sunny countries in the last 6 months compared to women who did not (28.1 ±3.1 ng/mL compared to 24.5 ±5.3 ng/mL, p = 0.0031); and normal weight or overweight women (according to body mass index (BMI)) compared to obese women (27.4 ±4.5 ng/mL compared to 22.3 ±4.7 ng/mL, p = 0.0431). In addition, 25(OH)D concentration correlated with total dietary vitamin D intake in the patient group (R = 0.17, p = 0.0021). Of all examined food groups, fish consumption affected serum 25(OH)D levels in patients (R = 0.20, p = 0.0421) and controls (R = 0.29, p = 0.0002). Consumption of fish products contributed to statistical differences between the patient group (R = 0.17, p = 0.0072) and healthy subjects (R = 0.19, p = 0.0032).
The most crucial factors influencing vitamin D status in the studied women were regular fish consumption, spending holidays in sunny destinations and regular intake of vitamin D preparations.
在欧洲，25(OH)D 缺乏的发生率被认为很高。因此，似乎有必要进行基于人群的研究，以充分评估各种患者群体中维生素 D 缺乏的情况。
评估波兰患有内分泌和骨质疏松症的女性的血清 25(OH)D 水平和缺乏频率。还研究了饮食、维生素/矿物质补充剂的使用以及暴露于紫外线（UVB）辐射对代谢紊乱女性维生素 D 状态的影响。
患者组由 223 名年龄在 19-81 岁之间的患有内分泌和/或骨质疏松症的女性组成。对照组由 108 名年龄在 26-72 岁之间的临床健康女性组成。使用化学发光免疫分析（CLIA）评估血清 25(OH)D 浓度。使用专门的问卷评估参与者的 UVB 辐射暴露情况。使用三天 24 小时问卷访谈评估食物摄入量。
以下组的 25(OH)D 水平显著更高：服用维生素 D 补充剂的女性与未服用维生素 D 补充剂的女性相比（29.3±3.2ng/mL 比 19.5±3.7ng/mL，p=0.0024）；绝经前女性与绝经后女性相比（28.9±5.2ng/mL 比 21.5±4.5ng/mL，p=0.0021）；在过去 6 个月中去过阳光充足国家的女性与未去过的女性相比（28.1±3.1ng/mL 比 24.5±5.3ng/mL，p=0.0031）；体重正常或超重的女性（根据身体质量指数（BMI））与肥胖女性相比（27.4±4.5ng/mL 比 22.3±4.7ng/mL，p=0.0431）。此外，25(OH)D 浓度与患者组的膳食维生素 D 总摄入量呈正相关（R=0.17，p=0.0021）。在所有检查的食物组中，鱼类消费影响患者（R=0.20，p=0.0421）和对照组（R=0.29，p=0.0002）的血清 25(OH)D 水平。鱼类制品的消费导致患者组（R=0.17，p=0.0072）和健康受试者组（R=0.19，p=0.0032）之间存在统计学差异。
影响研究女性维生素 D 状态的最关键因素是定期食用鱼类、在阳光充足的目的地度假以及定期摄入维生素 D 制剂。
