Peiser J, Ovnat A, Uwyyed K, Lavie P, Charuzi I
Clin Cardiol. 1985 Oct;8(10):519-21. doi: 10.1002/clc.4960081005.
Fourteen morbidly obese patients scheduled for gastric bypass surgery were diagnosed preoperatively as suffering from sleep apnea syndrome. There were 13 males and 1 female aged 24 to 59 years. Mean preoperative excessive body weight was 222 +/- 38%; mean apnea index prior to surgery was 84 +/- 44. A whole night lead II ECG tracing was performed as part of the polyhypnographic recordings and was evaluated for cardiac arrhythmias. Studies were performed in all patients preoperatively and 6 months thereafter. Statistical analysis was done using the Student's paired t-test. In this group a high incidence of atrial and ventricular arrhythmias was found. Marked sinus arrhythmia was encountered in all patients and extreme sinus bradycardia in 4 of them. In a consecutive sleep study performed 6 months postoperatively most cardiac arrhythmias disappeared. Marked sinus arrhythmia persisted in only two patients and severe ventricular premature beats (Lown's grade III-IV), found preoperatively in all patients, were still present postoperatively in only two, although in a much milder form. Surgical weight reduction, therefore, is a valuable method in the abolishment of life-threatening cardiac arrhythmias of the morbidly obese sleep-apneic patient.
14例计划接受胃旁路手术的病态肥胖患者术前被诊断患有睡眠呼吸暂停综合征。其中男性13例，女性1例，年龄在24至59岁之间。术前平均超重222±38%；术前平均呼吸暂停指数为84±44。作为多导睡眠图记录的一部分，进行了整晚的II导联心电图描记，并对心律失常进行了评估。在所有患者术前及术后6个月进行了研究。采用学生配对t检验进行统计分析。在该组中发现心房和心室心律失常的发生率很高。所有患者均出现明显的窦性心律失常，其中4例出现极度窦性心动过缓。在术后6个月进行的连续睡眠研究中，大多数心律失常消失。仅2例患者仍存在明显的窦性心律失常，术前所有患者均发现的严重室性早搏（洛恩分级III-IV级）术后仅2例仍存在，不过程度要轻得多。因此，手术减肥是消除病态肥胖睡眠呼吸暂停患者危及生命的心律失常的一种有效方法。
