苯妥英钠脑病病例报告。血清水平、癫痫发作增加与脑电图尖波和慢波活动之间的相关性。

A case report of phenytoin encephalopathy. Correlation between serum levels, seizure increase and E.E.G. spike and wave activity.

作者信息

Zwarts M J, Sie O

出版信息

Clin Neurol Neurosurg. 1985;87(3):205-8. doi: 10.1016/0303-8467(85)90008-3.

Abstract

In a case of phenytoin (PHT) encephalopathy a correlation was found between rising PHT serum levels and increase in seizure frequency. Supporting the correlation was the concomitant increase of E.E.G. spike and wave activity to 25% of the registration time. The rise in the PHT serum levels was possibly related to a drug interaction with carbamazepine. In addition neuropsychological assessment indicated reversible mental deterioration and deficits in motor skills and visual perception.

摘要

在一例苯妥英（PHT）脑病患者中，发现血清PHT水平升高与癫痫发作频率增加之间存在关联。支持这种关联的是，脑电图尖波和慢波活动同时增加至记录时间的25%。PHT血清水平升高可能与药物与卡马西平的相互作用有关。此外，神经心理学评估显示存在可逆性精神衰退以及运动技能和视觉感知缺陷。