Dilara Ertenu D, Salpekar Jay A
Neuropsychiatry Program, Kennedy Krieger Institute, Baltimore, MD, USA.
Johns Hopkins University School of Medicine; Baltimore, MD, USA.
Epilepsy Curr. 2025 Jun 16:15357597251350031. doi: 10.1177/15357597251350031.
This review provides a practical, evidence-informed approach to initiating pharmacologic treatment for children and adolescents with epilepsy who present with comorbid neuropsychiatric symptoms including depression, behavioral dyscontrol, and attention-deficit/hyperactivity disorder. The paper addresses how to determine when medication is warranted, outlines considerations for medication selection, and offers general principles for medication initiation and monitoring. Although the discourse is aimed at a pediatric population, the concepts are applicable to other ages as well. The goal is to provide clinicians with a decision-making framework to optimize both neurological and psychiatric outcomes in this complex population.
本综述提供了一种基于证据的实用方法，用于对患有癫痫且伴有共病神经精神症状（包括抑郁、行为失控和注意力缺陷多动障碍）的儿童和青少年启动药物治疗。本文阐述了如何确定何时需要用药，概述了药物选择的注意事项，并提供了药物起始和监测的一般原则。尽管本文论述的对象是儿科人群，但这些概念也适用于其他年龄段。目标是为临床医生提供一个决策框架，以优化这一复杂人群的神经和精神治疗效果。
