Souissi Amine, Prieto-González Pablo, Ben Saad Helmi
Faculté de Médecine de Sousse, Hôpital Farhat HACHED, Laboratoire de Recherche (Insuffisance Cardiaque, LR12SP09), Université de Sousse, Sousse, Tunisie.
Sport Sciences and Diagnostics Research Group, GSD-HPE Department, Prince Sultan University, Riyadh, Saudi Arabia.
Front Pain Res (Lausanne). 2025 Jun 4;6:1609095. doi: 10.3389/fpain.2025.1609095. eCollection 2025.
Long coronavirus disease 2019 (LC19) represents a complex global health challenge. Survivors frequently report persistent problems like widespread pain syndrome (WPS), cognitive dysfunction, cardiovascular complications, and sleep disturbances. These health problems, which are worsened by oxidative stress and inflammaging, open the prospect of treatment strategies targeting these mechanisms. Melatonin is a potential option for treating LC19 problems because of its anti-inflammatory, antioxidant, and pain-modulating properties. Melatonin targets shared pathological pathways, offering a promising approach to reducing inflammation, oxidative stress, and neuroendocrine dysfunction. The present mini-review explores the therapeutic potential of melatonin in the treatment of LC19, focusing on its effects on WPS and inflammation.
长期新冠病毒病（LC19）是一项复杂的全球健康挑战。康复者经常报告存在持续问题，如广泛性疼痛综合征（WPS）、认知功能障碍、心血管并发症和睡眠障碍。这些健康问题因氧化应激和炎症衰老而恶化，为针对这些机制的治疗策略开辟了前景。褪黑素因其抗炎、抗氧化和疼痛调节特性，是治疗LC19问题的一个潜在选择。褪黑素针对共同的病理途径，为减轻炎症、氧化应激和神经内分泌功能障碍提供了一种有前景的方法。本综述探讨了褪黑素在治疗LC19方面的治疗潜力，重点关注其对WPS和炎症的影响。
