Bertholf R L, Wills M R, Savory J
Clin Physiol Biochem. 1985;3(5):271-6.
Normal and uremic serum samples were chromatographed on a gel filtration column and fractions were analyzed for protein and aluminum content. Whereas much of the aluminum in the serum samples eluted with protein, a significant fraction appeared to be associated with low molecular weight species. Analysis of column fractions for aluminum binding by a competitive binding assay indicated no aluminum-binding serum constituents in these later eluting fractions. Uremic serum appeared, however, to contain aluminum-binding constituents of a lower molecular weight than in normal serum.
将正常血清样本和尿毒症血清样本在凝胶过滤柱上进行色谱分析，并对各馏分的蛋白质和铝含量进行分析。血清样本中的大部分铝与蛋白质一起洗脱，但有相当一部分似乎与低分子量物质有关。通过竞争性结合测定法对柱馏分的铝结合情况进行分析，结果表明这些较晚洗脱的馏分中不存在铝结合血清成分。然而，尿毒症血清似乎含有分子量比正常血清中更低的铝结合成分。
