King S W, Savory J, Wills M R
Ann Clin Lab Sci. 1982 Mar-Apr;12(2):143-9.
Aluminum is a toxic metal and has been implicated as the causative agent in the dialysis encephalopathy syndrome. In the study reported here, the transfer of aluminum to the blood from dialysis fluid during hemodialysis was demonstrated even when deionized water was used in the preparation of the dialysate. Studies were carried out on the binding of aluminum to serum proteins and other constituents in patients on long-term hemodialysis. Five major aluminum peaks were observed on chromatographic separation; four were associated with proteins and one large peak was probably associated with a low molecular weight species. The size of the latter peak was enhanced by increasing the aluminum content of the eluting buffer. It is postulated that this low molecular weight species might be the neurotoxic form of aluminum.
铝是一种有毒金属，被认为是透析性脑病综合征的致病因素。在本文报道的研究中，即使在制备透析液时使用去离子水，也证明了血液透析期间铝从透析液转移至血液中。对长期接受血液透析患者体内铝与血清蛋白及其他成分的结合情况进行了研究。色谱分离时观察到五个主要的铝峰；四个与蛋白质相关，一个大峰可能与低分子量物质有关。通过增加洗脱缓冲液中的铝含量，后一个峰的大小会增强。据推测，这种低分子量物质可能是铝的神经毒性形式。
