Matson Kelly L, Forbes Clara L, Burton Katelyn E
Department of Pharmacy Practice (KLM), University of Rhode Island, Kingston, RI.
Department of Pharmacy (CLF), Brigham and Women's Hospital, Boston, MA.
J Pediatr Pharmacol Ther. 2025 Jun;30(3):367-371. doi: 10.5863/JPPT-23-00084. Epub 2025 Jun 9.
Celiac disease and gluten sensitivities are on the rise, with a greater prevalence of the condition in children than adults. Resources to ascertain gluten content exist but can be incomplete and focus on medications for adults. The objective of this research is to determine gluten-free status of the top 100 pediatric medications dispensed.
The top 100 pediatric medications were identified by using Optum Clinformatics Data Mart database. After list creation, manufacturers and National Drug Code (NDC) for each drug were procured and used to contact manufacturers directly for gluten content information.
Evaluation of 689 NDCs was completed with 50.2% of medications documented to be gluten-free. Additional categories were confirmed gluten-free but cannot confirm cross-contamination (22.6%), cannot confirm gluten-free (25.7%), and contains gluten (1.5%). Resource tables were developed from findings though information may change, based on manufacturing ingredients and processing.
Pediatric medications differ in gluten content, compared with medications for adults. Incomplete information exists regarding gluten content of medications, especially pediatric resources. Development of a pediatric-specific resource for gluten content of commonly dispensed medications in children and adolescents will hopefully benefit patients with celiac disease.
乳糜泻和麸质敏感性疾病的发病率正在上升，儿童中的患病率高于成人。目前有确定麸质含量的资源，但可能不完整且侧重于成人用药。本研究的目的是确定所配发的前100种儿科药物的无麸质状态。
通过使用Optum临床信息数据集市数据库确定前100种儿科药物。列表创建后，获取每种药物的制造商和国家药品代码（NDC），并用于直接联系制造商获取麸质含量信息。
完成了对689个NDC的评估，其中50.2%的药物记录为无麸质。其他类别被确认为无麸质但无法确认是否存在交叉污染（22.6%）、无法确认无麸质（25.7%）以及含有麸质（1.5%）。根据研究结果编制了资源表，不过信息可能会因生产成分和加工过程而改变。
与成人用药相比，儿科药物的麸质含量有所不同。关于药物麸质含量的信息不完整，尤其是儿科方面的资源。开发针对儿童和青少年常用药物麸质含量的儿科专用资源有望使乳糜泻患者受益。
