Nie Fulei, Song Xiaoming, Chen Wei
School of Public Health, North China University of Science and Technology, Tangshan 063210, China.
School of Life Sciences, North China University of Science and Technology, Tangshan 063210, China.
Mol Ther Nucleic Acids. 2025 May 27;36(3):102576. doi: 10.1016/j.omtn.2025.102576. eCollection 2025 Sep 9.
Diabetes is a prevalent chronic disease that poses a significant burden on individuals and healthcare systems. Early diagnosis and effective management are essential for delaying disease onset and minimizing complications. In this study, we developed a deep learning-based risk prediction model using data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2011 to 2018. From an initial set of 36 variables, and through feature selection, five key features were identified through feature selection techniques to construct the model. The model demonstrated robust performance, accurately predicting diabetes risk with high precision in test data. External validation further confirmed its ability to correctly identify individuals at risk of developing diabetes. To enhance its practical application, we implemented a risk stratification system and developed a user-friendly online tool, available at http://cbcb.cdutcm.edu.cn/drpm/, allowing easy access for users. This model provides a valuable tool for diabetes risk screening and personalized early detection.
糖尿病是一种常见的慢性疾病,给个人和医疗系统带来了沉重负担。早期诊断和有效管理对于延缓疾病发作和减少并发症至关重要。在本研究中,我们利用2011年至2018年美国国家健康与营养检查调查(NHANES)的数据开发了一种基于深度学习的风险预测模型。从最初的36个变量集中,通过特征选择技术识别出五个关键特征来构建模型。该模型表现出强大的性能,在测试数据中以高精度准确预测糖尿病风险。外部验证进一步证实了其正确识别有患糖尿病风险个体的能力。为了增强其实际应用,我们实施了风险分层系统并开发了一个用户友好的在线工具,可在http://cbcb.cdutcm.edu.cn/drpm/获取,方便用户使用。该模型为糖尿病风险筛查和个性化早期检测提供了一个有价值的工具。