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基于阴阳理论探讨巨噬细胞极化在慢性鼻-鼻窦炎中的作用：综述

Role of Macrophage Polarization in Chronic Rhinosinusitis Based on the Yin-Yang Theory: A Review.

作者信息

Wang Fei, Xiong Ye, Zhu Yaxian, Yang Xiaoqian, Liu Kai, Zhu Zhenhua

机构信息

Department of Otolaryngology, The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, People's Republic of China.

出版信息

J Inflamm Res. 2025 Jun 13;18:7813-7825. doi: 10.2147/JIR.S514060. eCollection 2025.

DOI:10.2147/JIR.S514060
PMID:40535355
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12174917/
Abstract

BACKGROUND

Chronic rhinosinusitis (CRS) is a prevalent otolaryngologic condition that markedly impacts patients' quality of life; however its pathogenesis is intricate and the clinical efficacy of known treatments remains limited.

METHODS

In recent years, there has been a growing focus on the role of immune function in the pathogenesis of CRS. Recent studies have revealed a correlation between macrophage polarization and CRS development. Macrophage polarization denotes distinct phenotypes of macrophages in diverse microenvironments, with the M1 and M2 phenotypes sharing similarities with the Yin-Yang concept of traditional Chinese medicine, encompassing mutual support and utilization, a balance between growth and elimination, and self-healing and equilibrium.

RESULTS

This study briefly reviews the latest research on traditional Chinese medicine compound prescriptions and the regulation of macrophage polarization by traditional Chinese medicine monomers, aligned with the main treatment principles of CRS, with the aim of offering novel directions and strategies for the clinical management of this condition.

CONCLUSION

This study investigated the role of macrophage polarization in CRS from the perspective of the Yin-Yang Theory of traditional Chinese medicine.

摘要

背景

慢性鼻-鼻窦炎（CRS）是一种常见的耳鼻喉科疾病，严重影响患者的生活质量；然而，其发病机制复杂，已知治疗方法的临床疗效仍然有限。

方法

近年来，免疫功能在CRS发病机制中的作用受到越来越多的关注。最近的研究揭示了巨噬细胞极化与CRS发展之间的相关性。巨噬细胞极化指巨噬细胞在不同微环境中的不同表型，M1和M2表型与中医阴阳概念有相似之处，包括相互支持与利用、生长与消除的平衡以及自我修复与平衡。

结果

本研究简要回顾了与CRS主要治疗原则相关的中药复方及中药单体对巨噬细胞极化调节的最新研究，旨在为该病的临床治疗提供新的方向和策略。

结论

本研究从中医学阴阳理论的角度探讨了巨噬细胞极化在CRS中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e83d/12174917/98c45488c257/JIR-18-7813-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e83d/12174917/180c51b6e486/JIR-18-7813-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e83d/12174917/4a3d3c0cd8ed/JIR-18-7813-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e83d/12174917/5bdec80f624b/JIR-18-7813-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e83d/12174917/98c45488c257/JIR-18-7813-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e83d/12174917/180c51b6e486/JIR-18-7813-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e83d/12174917/4a3d3c0cd8ed/JIR-18-7813-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e83d/12174917/5bdec80f624b/JIR-18-7813-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e83d/12174917/98c45488c257/JIR-18-7813-g0004.jpg

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