A型肉毒杆菌毒素注射在治疗老年患者面肌痉挛方面显示出显著疗效。
Botulinum toxin type A injections demonstrate remarkable efficacy in treating hemifacial spasm in elderly patients.
作者信息
Cao Lihua, Bai Min, Li Chao, Sheng Weiwei, Zhou Dingjie, Wang Xiaolei
机构信息
Department of Geriatric Medicine, Nanjing Pukou People's Hospital Nanjing 211800, Jiangsu, China.
Jiangsu Health Development Research Center, NHC Contraceptive Adverse Reaction Surveillance Center, Jiangsu Provincial Medical Key Laboratory of Fertility Protection and Health Technology Assessment Nanjing 210036, Jiangsu, China.
出版信息
Am J Transl Res. 2025 May 15;17(5):3674-3682. doi: 10.62347/JQNB3235. eCollection 2025.
OBJECTIVE
To investigate the effectiveness of botulinum toxin type A (BTX-A) injections in elderly patients with hemifacial spasm (HFS).
METHODS
In this retrospective study, a total of 120 elderly patients diagnosed with HFS were recruited and divided into two groups: a research group (n=65) receiving multi-point BTX-A injections and a control group (n=55) undergoing conventional treatment. Comparative analyses were conducted to evaluate therapeutic efficacy, duration of efficacy, adverse reactions, Hamilton Anxiety Scale (HAMA) scores, and Hamilton Depression Scale (HAMD) scores between the two groups. Furthermore, factors influencing treatment outcomes in elderly HFS patients were investigated.
RESULTS
The research group demonstrated significantly higher overall efficacy, prolonged durations of therapeutic efficacy in grades II, III, and IV, a lower incidence of adverse reactions, and more pronounced improvements in HAMA and HAMD scores. Additionally, Cohen grading, HAMA and HAMD scores, and the treatment approach were independently correlated with treatment failure in elderly patients.
CONCLUSION
Multi-point BTX-A injections are highly effective in treating HFS in elderly patients.
目的
探讨A型肉毒毒素（BTX-A）注射治疗老年面肌痉挛（HFS）患者的有效性。
方法
在这项回顾性研究中，共招募了120例诊断为HFS的老年患者，并将其分为两组：研究组（n = 65）接受多点BTX-A注射，对照组（n = 55）接受传统治疗。对两组之间的治疗效果、疗效持续时间、不良反应、汉密尔顿焦虑量表（HAMA）评分和汉密尔顿抑郁量表（HAMD）评分进行比较分析。此外，还研究了影响老年HFS患者治疗结果的因素。
结果
研究组总体疗效显著更高，II级、III级和IV级的疗效持续时间延长，不良反应发生率更低，HAMA和HAMD评分改善更明显。此外，Cohen分级、HAMA和HAMD评分以及治疗方法与老年患者治疗失败独立相关。
结论
多点BTX-A注射治疗老年HFS患者疗效显著。
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