Natarajan Peter, Ng Khai Lip, Huan Nai-Chien, Chong Ad Rian, Momin Najah, Mohd Aminudin Nur Husna, Hassan Nor Hafizah Abu, Mohamed Nordin Kasuma
Division of Respiratory Medicine, Department of Internal Medicine Melaka Hospital Melaka Malaysia.
Department of Respiratory Medicine Queen Elizabeth Hospital Kota Kinabalu Sabah Malaysia.
Respirol Case Rep. 2025 Jun 18;13(6):e70254. doi: 10.1002/rcr2.70254. eCollection 2025 Jun.
Constitutional symptoms and lymphadenopathy are cardinal features of Hodgkin's lymphoma (HL), a malignant lymphoproliferative disorder. While mediastinal involvement is frequently observed, endobronchial HL is a rare and challenging presentation. We report a 23-year-old gentleman who presented with a persistent cough, weight loss and a large cavitating lung mass. Microbiological investigations yielded negative results but flexible bronchoscopy (FB) revealed multiple endobronchial masses. Subsequent pathological examination confirmed the diagnosis of HL, mixed cellularity subtype. This case highlights the importance of considering HL in the differentials of endobronchial masses and lung cavities, particularly when initial investigations fail to identify a clear cause.
全身症状和淋巴结病是霍奇金淋巴瘤(HL)的主要特征,HL是一种恶性淋巴增殖性疾病。虽然纵隔受累很常见,但支气管内HL是一种罕见且具有挑战性的表现形式。我们报告了一名23岁男性,他出现持续咳嗽、体重减轻和一个大的肺空洞性肿块。微生物学检查结果为阴性,但纤维支气管镜检查(FB)发现多个支气管内肿块。随后的病理检查确诊为HL,混合细胞型。该病例强调了在支气管内肿块和肺空洞的鉴别诊断中考虑HL的重要性,特别是当初步检查未能明确病因时。