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泛癌分析确定DBF4B为一种免疫和预后生物标志物。

Pan-cancer analysis identifies DBF4B as an immunologic and prognostic biomarker.

作者信息

Qin Chongjiu, Chen Yu, Qin Haifei, Huang Xinlei, Xie Haixiang, Yang Kejian, Liu Junqi, Zhou Xin, Liao Xiwen, Han Chuangye, Su Hao, Yan Guohong, Wan Zuying, Peng Tao, Zhu Guangzhi

机构信息

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, People's Republic of China.

Guangxi Key Laboratory of Enhanced Recovery after Surgery for Gastrointestinal Cancer, 530021, Nanning, People's Republic of China.

出版信息

J Cancer. 2025 Jun 12;16(8):2626-2648. doi: 10.7150/jca.109134. eCollection 2025.

DOI:10.7150/jca.109134
PMID:40535802
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12170996/
Abstract

DBF4 zinc finger B (DBF4B) is a regulator of cellular CDC7 proteins, and the complex it forms with CDC7 proteins plays a key role in coordinating the initiation of DNA replication. Compared with previous DBF4B studies, this study is the first to use a publicly available database to explore DBF4B differential expression and prognosis in different cancers, as well as its association with gene mutations, molecular and immune subtypes, immune infiltration, methylation, and drug sensitivity. Our results showed that DBF4B was significantly differentially expressed in most cancer types as well as in cancers with different molecular and immune subtypes, and DBF4B was also significantly correlated with the prognosis of a subset of cancers. Furthermore, our analysis showed that DBF4B expression in liver hepatocellular carcinoma (LIHC) was associated with a variety of factors, including age, gender, race, height, weight, body mass index (BMI), presence of residual tumor, and tumor status. Elevated DBF4B expression was correlated with poorer overall survival (OS), disease-specific survival (DSS), and progression-free interval (PFI). especially in different clinical subtypes. In conclusion, DBF4B may be a key molecular biomarker for pan-cancer immunology and prognosis and an independent prognostic risk factor for LIHC.

摘要

DBF4锌指蛋白B（DBF4B）是细胞CDC7蛋白的调节因子，它与CDC7蛋白形成的复合物在协调DNA复制起始过程中起关键作用。与以往关于DBF4B的研究相比，本研究首次利用公开数据库探讨DBF4B在不同癌症中的差异表达和预后情况，以及它与基因突变、分子和免疫亚型、免疫浸润、甲基化和药物敏感性的关系。我们的结果表明，DBF4B在大多数癌症类型以及具有不同分子和免疫亚型的癌症中均有显著差异表达，并且DBF4B还与一部分癌症的预后显著相关。此外，我们的分析表明，DBF4B在肝细胞癌（LIHC）中的表达与多种因素相关，包括年龄、性别、种族、身高、体重、体重指数（BMI）、残留肿瘤的存在以及肿瘤状态。DBF4B表达升高与较差的总生存期（OS）、疾病特异性生存期（DSS）和无进展生存期（PFI）相关，尤其是在不同的临床亚型中。总之，DBF4B可能是泛癌免疫学和预后的关键分子生物标志物，也是LIHC的独立预后危险因素。

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本文引用的文献

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Pan-cancer analysis of PLAU indicates its potential prognostic value and correlation with neutrophil infiltration in BLCA.PLAU 在多种癌症中的分析表明其在 BLCA 中具有潜在的预后价值，并与中性粒细胞浸润相关。
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Integrative analysis identifies AKAP8L as an immunological and prognostic biomarker of pan-cancer.
整合分析鉴定 AKAP8L 为泛癌的免疫和预后生物标志物。
Aging (Albany NY). 2023 Sep 7;15(17):8851-8872. doi: 10.18632/aging.205003.
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Comprehensive Pan-Cancer Analysis of KIF18A as a Marker for Prognosis and Immunity.全面泛癌分析 KIF18A 作为预后和免疫标志物。
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The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest.2023 年的 STRING 数据库：针对任何感兴趣的测序基因组的蛋白质-蛋白质关联网络和功能富集分析。
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