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AA-amyloidosis in dogs: partial amino acid sequence of protein AA and immunohistochemical cross-reactivity with human and cow AA-amyloid.

作者信息

Westermark P, Johnson K H, Sletten K, Hayden D W

出版信息

Comp Biochem Physiol B. 1985;82(2):211-5. doi: 10.1016/0305-0491(85)90228-7.

DOI:10.1016/0305-0491(85)90228-7
PMID:4053581
Abstract

Protein AA was purified from the kidneys of dogs with spontaneous reactive amyloidosis. The protein had a blocked N-terminal. Sequence analysis of a peptide obtained after cyanogen bromide cleavage revealed an amino acid sequence corresponding to positions 24-42 of human AA. This region showed a strong homology to protein AA of other species. Antiserum to both human and dog protein AA reacted immunohistochemically with AA amyloid of human, dog and cow origin.

摘要

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