Racke Caroline A, Keim Sarah A, Yisahak Samrawit F, Stith Briana J, Thung Stephen F, Klebanoff Mark A, Gabbe Steven G, Landon Mark B, Oza-Frank Reena
Center for Biobehavioral Health, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH, USA.
Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA.
Am J Lifestyle Med. 2025 Jun 14:15598276251351809. doi: 10.1177/15598276251351809.
This parallel two-arm, randomized, controlled trial (RCT) tested the efficacy of wearing ankle weights during daily activities (e.g., childcare and housework) on body weight and composition changes, and glycemic, lipid, and inflammatory biomarkers in postpartum women diagnosed with gestational diabetes mellitus (GDM) during pregnancy.
The intervention group (1.1 kgs each, 2 hours/day, from 25-35 to 190-210 days' postpartum) was compared to a standard-of-care control group in women with GDM during pregnancy. The primary outcome was body weight. Secondary outcomes included body composition and glycemic, lipid, and inflammatory biomarkers. Linear mixed models with time*treatment arm interaction compared changes in outcomes among the intervention group (ANK, n = 18) and control group (CTRL, n = 21), adjusted for clinic site and pre-pregnancy body mass index (BMI) category.
The intervention had no significant effect on weight change (mean (SD): 3.8 (1.8) kg for ANK vs 2.2 (1.6) kg for CTRL, P-for-interaction = 0.61) or percent body fat (-0.6 (0.9) for ANK vs -1.5 (0.8) for CTRL, P-for-interaction = 0.52). Both groups reduced their total cholesterol, but there was no intervention effect on this change (-25.3 (7.3) mg/dL for ANK vs -18.5 (6.7) mg/dL for CTRL, P-for-interaction = 0.40) or on other secondary outcomes. Registered under ) on Clinicaltrials.gov NCT03664089 (https://clinicaltrials.gov/study/NCT03664089?term=NCT03664089&rank=1).
本平行双臂随机对照试验（RCT）检验了产后被诊断为妊娠期糖尿病（GDM）的女性在日常活动（如照顾孩子和做家务）时佩戴踝部负重对体重、身体成分变化以及血糖、血脂和炎症生物标志物的影响。
将干预组（产后25 - 35天至190 - 210天，每天2小时，每组1.1千克）与妊娠期患有GDM的女性的标准护理对照组进行比较。主要结局是体重。次要结局包括身体成分以及血糖、血脂和炎症生物标志物。采用具有时间*治疗组交互作用的线性混合模型比较干预组（ANK，n = 18）和对照组（CTRL，n = 21）之间的结局变化，并根据诊所地点和孕前体重指数（BMI）类别进行调整。
干预对体重变化（平均值（标准差）：ANK组为3.8（1.8）千克，CTRL组为2.2（1.6）千克，交互作用P值 = 0.61）或体脂百分比（ANK组为 - 0.6（0.9），CTRL组为 - 1.5（0.8），交互作用P值 = 0.52）无显著影响。两组的总胆固醇均有所降低，但干预对此变化无影响（ANK组为 - 25.3（7.3）mg/dL，CTRL组为 - 18.5（6.7）mg/dL，交互作用P值 = 0.40），对其他次要结局也无影响。在Clinicaltrials.gov上注册，注册号为NCT03664089（https://clinicaltrials.gov/study/NCT03664089?term=NCT03664089&rank=1）。
