[阴茎发育不全（小阴茎）。25例系列病例的病因学资料]

[Insufficiency of penis development (micropenis). Etiological data in a series of 25 cases].

作者信息

Vanelli M, Chaussain J L, Vassal J, Job J C

出版信息

Arch Fr Pediatr. 1979 May;36(5):471-8.

Abstract

The diagnosis of micropenis was made in 25 boys aged 1 month to 16 years. This abnormality was associated with hypothalamic-pituitary deficiency in 12 boys (hypogonadotrophic hypogonadism, hypopituitary growth failure, Prader-Willi syndrome), with testicular disorders in 5 boys (anorchia, testicular dysgenesis). In the other 8 the micropenis was an isolated finding but the testicular response to HCG and the LH response to LHRH was significantly reduced (p less than 0.005). The results suggest there may be isolated gonadotrophia deficiency. The variety of conditions that are responsible for micropenis suggest that testosterone deficiency is an important causative factor. HGH may also be important as the penis may be small in HGH deficiency and growth occurs with treatment.

摘要

对25名年龄在1个月至16岁的男孩进行了小阴茎的诊断。这种异常情况在12名男孩中与下丘脑 - 垂体功能减退有关（性腺功能减退性性腺功能减退、垂体功能减退性生长发育迟缓、普拉德 - 威利综合征），在5名男孩中与睾丸疾病有关（无睾症、睾丸发育不全）。在另外8名男孩中，小阴茎是唯一的发现，但睾丸对人绒毛膜促性腺激素（HCG）的反应以及促黄体生成素（LH）对促性腺激素释放激素（LHRH）的反应显著降低（p < 0.005）。结果表明可能存在孤立性促性腺激素缺乏。导致小阴茎的多种情况表明睾酮缺乏是一个重要的致病因素。生长激素（HGH）也可能很重要，因为在生长激素缺乏时阴茎可能较小，而治疗后会出现生长。