Lee P A, Danish R K, Mazur T, Migeon C J
Johns Hopkins Med J. 1980 Nov;147(5):175-81.
This paper, the third in a series, presents data from 28 patients with micropenis categorized as primary hypogonadism (11 subjects), partial androgen insensitivity (1 subject), idiopathic (6 subjects), and etiology undetermined (10 subjects). Among the 11 patients with primary hypogonadism, 8 presented with various degrees of gonadal dysgenesis, 1 was a true hermaphrodite and 2 had the Robinow syndrome. Nine of the 28 patients were raised as females: 5 with primary hypogonadism and 4 with undetermined etiology. Eleven of the 19 patients raised as males received androgen stimulation during prepubertal years and responded with penile growth. However, this growth response was temporary and did not appear to be predictive of eventual adult size of the penis. Generally, the prestimulation size of this group of patients is more predictive of adult penile size. Only 7 of the patients raised as males have attained adult somatic growth. Three out of the three with primary hypogonadism, the subject with partial androgen insensitivity, and one of three with idiopathic micropenis have below-normal adult penile length. These limited data suggest that growth potential of the micropenis may be greater among the patients with an idiopathic state than among those with primary hypogonadism and partial androgen insensitivity.
本文是系列文章中的第三篇，呈现了28例小阴茎患者的数据，这些患者被分类为原发性性腺功能减退（11例）、部分雄激素不敏感（1例）、特发性（6例）以及病因未明（10例）。在11例原发性性腺功能减退患者中，8例呈现出不同程度的性腺发育不全，1例为真两性畸形，2例患有Robinow综合征。28例患者中有9例被当作女性抚养：5例为原发性性腺功能减退，4例病因未明。在19例被当作男性抚养的患者中，11例在青春期前接受了雄激素刺激，阴茎出现生长反应。然而，这种生长反应是暂时的，似乎无法预测阴茎最终的成人大小。一般来说，这组患者刺激前的大小更能预测成人阴茎大小。只有7例被当作男性抚养的患者达到了成人躯体生长状态。原发性性腺功能减退的3例患者、部分雄激素不敏感的患者以及3例特发性小阴茎患者中的1例，其成人阴茎长度低于正常水平。这些有限的数据表明，特发性状态患者中小阴茎的生长潜力可能大于原发性性腺功能减退和部分雄激素不敏感患者。
