Luknárová O, Kusá O, Riecanský I, Zelenay J
Cor Vasa. 1985;27(4):266-71.
The relationship between serum lipid and lipoprotein concentration and the severity of coronary artery disease assessed by cineangiography was studied in 38 male patients, aged 44 +/- 11.5 years. According to luminal diameter narrowing of 3 major coronary arteries, the patients were divided into 3 groups: group A -- 10 patients with a normal coronarographic finding; group B -- 8 patients with a 26 to 50% coronary artery stenosis; group C -- 20 men with coronary stenosis exceeding 51%. With the exception of Apo B which in patients of group B was slightly elevated (p less than 0.05), there was no difference in serum lipid and lipoprotein levels between patients of group A and B. Patients of group C had significantly increased Apo B and triglyceride levels and a decreased high density lipoproteins (HDL) cholesterol/total cholesterol ratio in comparison with the control group. In group C, a linear correlation was found between the number of affected major coronary arteries and the serum Apo B level. The results suggest that determination of Apo B, triglycerides and the HDL cholesterol/total cholesterol ratio contributes to assessing the severity of coronary heart disease.
对38名年龄在44±11.5岁的男性患者进行了研究，以探讨血清脂质和脂蛋白浓度与通过血管造影评估的冠状动脉疾病严重程度之间的关系。根据3条主要冠状动脉的管腔直径狭窄情况，将患者分为3组：A组——10名冠状动脉造影结果正常的患者；B组——8名冠状动脉狭窄26%至50%的患者；C组——20名冠状动脉狭窄超过51%的男性。除B组患者的载脂蛋白B略有升高外（p<0.05），A组和B组患者的血清脂质和脂蛋白水平无差异。与对照组相比，C组患者的载脂蛋白B和甘油三酯水平显著升高，高密度脂蛋白（HDL）胆固醇/总胆固醇比值降低。在C组中，发现受影响的主要冠状动脉数量与血清载脂蛋白B水平之间存在线性相关性。结果表明，测定载脂蛋白B、甘油三酯和HDL胆固醇/总胆固醇比值有助于评估冠心病的严重程度。
