Li Junjiao, Dong Yuanyuan, Chen Wei, Wang Jian, Zheng Xifu
College of Teacher Education, Guangdong University of Education, Guangzhou, China.
School of Psychology, South China Normal University, Guangzhou, China.
Addict Biol. 2025 Jun;30(6):e70049. doi: 10.1111/adb.70049.
Post-retrieval interventions based on memory reconsolidation have shown promise in reducing addiction-related memories. However, research on methamphetamine (MA) use, particularly in humans, remains limited. This study aimed to evaluate the efficacy of a post-retrieval intervention paradigm in managing methamphetamine use disorder (MUD) with 46 individuals from a compulsory drug rehabilitation centre. A single-blind design was employed, with participants randomly assigned to one of three groups: (1) retrieval-no intervention, (2) retrieval-extinction and (3) retrieval-cognitive task. The study involved baseline testing, followed by memory retrieval using MA cues, and one of the three interventions during the memory reconsolidation window. The interventions were as follows: (1) no further intervention after retrieval, (2) extinction training and (3) playing Tetris after memory reactivation. Relapse was assessed through physiological and psychological indicators, with a focus on both spontaneous and cue-induced relapse of MUD memory. The results showed that both retrieval-extinction and retrieval-cognitive task showed benefits in reducing cravings and preventing relapse in MUD compared to retrieval alone. Physiological and psychological indicators of MA memory relapse showed weak correlation and differed across several dimensions. These findings suggest new strategies for MUD intervention and provide valuable insights for clinical treatment. Limitations of the study are also discussed.
基于记忆重新巩固的检索后干预在减少成瘾相关记忆方面已显示出前景。然而，关于甲基苯丙胺（MA）使用的研究，尤其是在人类中的研究，仍然有限。本研究旨在评估一种检索后干预范式对来自强制戒毒中心的46名个体管理甲基苯丙胺使用障碍（MUD）的疗效。采用单盲设计，参与者被随机分配到三组之一：（1）检索-无干预，（2）检索-消退和（3）检索-认知任务。该研究包括基线测试，随后使用MA线索进行记忆检索，以及在记忆重新巩固窗口期间进行三种干预之一。干预措施如下：（1）检索后不进行进一步干预，（2）消退训练和（3）记忆重新激活后玩俄罗斯方块。通过生理和心理指标评估复发情况，重点关注MUD记忆的自发和线索诱导复发。结果表明，与单独检索相比，检索-消退和检索-认知任务在减少MUD的渴望和预防复发方面均显示出益处。MA记忆复发的生理和心理指标显示出弱相关性，并且在几个维度上有所不同。这些发现为MUD干预提出了新策略，并为临床治疗提供了有价值的见解。本研究的局限性也进行了讨论。
