Mahmoud Eman Ibrahim El-Desoki, Awdallah Faten Farid
Intensive care medicine, National Hepatology and Tropical Medicine Research Institute (NHTNMRI), General Organization of Teaching Hospitals and institutes (GOTHI), Cairo, Egypt.
Intensive care medicine, National Heart Institute, GOTHI, Cairo, Egypt.
BMC Gastroenterol. 2025 Jun 19;25(1):439. doi: 10.1186/s12876-025-03696-3.
Several animal studies have shown that Branched-chain amino acids (BCAAs) may prevent acute liver injury, although its effects in humans are as yet undetermined. Thus the purpose of this study is to evaluate the impact of intravenous BCAAs infusion on liver profile post-liver surgery in the intensive care unit (ICU).
A randomized study that was applied for post liver surgery patients who were randomly allocated to receive either intravenous BCAA immediately post-operative or placebo.
Follow-up liver profile, Child-Pugh, and SOFA scores during the first week post-surgery.
A significant decline of bilirubin and ALT on day three and five in the BCAA group compared to the control group respectively. There was a significant improvement of PT on day seven 12.5 in the BCAA group versus 12.9 in the control group, p-value 0.01. Total bilirubin levels decreased by 75% in the BCAA group, whereas in the control group saw an increase of 6.25% from the baseline which was statistically significant, p-value 0.0376. SOFA score was markedly improved in the BCAA group (p-value 0.013). In addition to a significantly shorter ICU stay in the BCAA group than in the control group (p-value 0.018).
There are beneficial effects of BCAAs infusion post-liver surgery; including improved metabolic profile (liver function tests), and shorter ICU stay.
(Clinicaltrials.gov registration number:NCT03448848), 28/02/2018.
多项动物研究表明，支链氨基酸（BCAAs）可能预防急性肝损伤，但其对人类的影响尚未确定。因此，本研究的目的是评估在重症监护病房（ICU）中，静脉输注BCAAs对肝脏手术后肝脏指标的影响。
一项随机研究，应用于肝切除术后患者，这些患者被随机分配在术后立即接受静脉BCAAs或安慰剂。
术后第一周的肝脏指标、Child-Pugh评分和序贯器官衰竭评估（SOFA）评分。
与对照组相比，BCAA组在术后第三天和第五天胆红素和谷丙转氨酶（ALT）显著下降。BCAA组在术后第七天凝血酶原时间（PT）显著改善，为12.5，而对照组为12.9，p值为0.01。BCAA组总胆红素水平下降了75%，而对照组较基线水平增加了6.25%，具有统计学意义，p值为0.0376。BCAA组SOFA评分显著改善（p值为0.013）。此外，BCAA组在ICU的住院时间明显短于对照组（p值为0.018）。
肝脏手术后输注BCAAs有有益效果；包括改善代谢指标（肝功能测试）和缩短ICU住院时间。
（Clinicaltrials.gov注册号：NCT03448848），2018年2月28日。
