肝脏疾病中的支链氨基酸
Branched-chain amino acids in liver diseases.
作者信息
Tajiri Kazuto, Shimizu Yukihiro
机构信息
Department of Gastroenterology, Toyama University Hospital, Toyama, Japan.
Gastroenterology Unit, Nanto Municipal Hospital, Nanto, Japan.
出版信息
Transl Gastroenterol Hepatol. 2018 Jul 30;3:47. doi: 10.21037/tgh.2018.07.06. eCollection 2018.
Abstract
Branched chain amino acids (BCAAs) are involved in various bioprocess such as protein metabolism, gene expression, insulin resistance and proliferation of hepatocytes. BCAAs have also been reported to suppress the growth of hepatocellular carcinoma (HCC) cells and to be required for immune cells to perform the function. In advanced cirrhotic patients, it has been clarified that serum concentrations of BCAA are decreased, whereas those of aromatic amino acids (AAAs) are increased. These alterations are thought to be the causes of hepatic encephalopathy (HE), sarcopenia and hepatocarcinogenesis and may be associated with the poor prognosis of patients with these conditions. Administration of BCAA-rich medicines has shown positive results in patients with cirrhosis.
摘要
支链氨基酸（BCAAs）参与多种生物过程，如蛋白质代谢、基因表达、胰岛素抵抗和肝细胞增殖。据报道，BCAAs还能抑制肝细胞癌（HCC）细胞的生长，并且是免疫细胞发挥功能所必需的。在晚期肝硬化患者中，已明确血清BCAA浓度降低，而芳香族氨基酸（AAAs）浓度升高。这些改变被认为是肝性脑病（HE）、肌肉减少症和肝癌发生的原因，可能与患有这些疾病患者的不良预后有关。给予富含BCAA的药物已在肝硬化患者中显示出积极效果。
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